اومیکس در عمل بالینی: ژنومیک، داروژنتیک، پروتئومیک و ترنسکریپتومیک در تحقیقات بالینی

This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized med. Read more... Content: Front Cover; About the Editor; Contents; Acknowledgment and How to Cite; List of Contributors; Introduction; Part I: Omics and Human Disease; Chapter 1: Comparative Mitochondrial Proteomics: Perspective in Human Diseases; Chapter 2: Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches; Chapter 3: Next Generation Sequencing in Cancer Research and Clinical Application; Chapter 4: Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice Part II: Translational and Personalized MedicineChapter 5: Clinical Proteomics and Omics Clues Useful in Translational Medicine Research; Chapter 6: Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data; Part III: Molecular and Genetic Markers; Chapter 7: Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine; Chapter 8: How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles, and Automated Microscopic Image Analyses for Clinical Needs and Public Health Chapter 9: Application of ''Omics'' to Prion Biomarker DiscoveryPart IV: Omics and Pathogens; Chapter 10: Insights from Genomics into Bacterial Pathogen Populations; Chapter 11: High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach; Chapter 12: Coronavirus Genomics and Bioinformatics Analysis; Part V: Companion Diagnostics; Chapter 13: Applications of Next-Generation Sequencing Technologies to Diagnostic Virology Abstract: This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized med Front Cover 1 About the Editor 6 Contents 8 Acknowledgment and How to Cite 12 List of Contributors 14 Introduction 20 Part I: Omics and Human Disease 28 Chapter 1: Comparative Mitochondrial Proteomics: Perspective in Human Diseases 30 Chapter 2: Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches 58 Chapter 3: Next Generation Sequencing in Cancer Research and Clinical Application 100 Chapter 4: Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice 124 Part II: Translational and Personalized Medicine 164 Chapter 5: Clinical Proteomics and Omics Clues Useful in Translational Medicine Research 166 Chapter 6: Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data 192 Part III: Molecular and Genetic Markers 206 Chapter 7: Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine 208 Chapter 8: How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles, and Automated Microscopic Image Analyses for Clinical Needs and Public Health 232 Chapter 9: Application of “Omics” to Prion Biomarker Discovery 274 Part IV: Omics and Pathogens 306 Chapter 10: Insights from Genomics into Bacterial Pathogen Populations 308 Chapter 11: High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach 332 Chapter 12: Coronavirus Genomics and Bioinformatics Analysis 354 Part V: Companion Diagnostics 378 Chapter 13: Applications of Next-Generation Sequencing Technologies to Diagnostic Virology 380 Chapter 14: Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture 410 Author Notes 448