OECD Guidelines for the Testing of Chemicals / Section 1: Physical-Chemical properties Test No. 104: Vapour Pressure

Abstract: This Test Guideline describes eight methods to measure the vapour pressure. Each one can be applied in different vapour pressure ranges. The vapour pressure (in Pascal) of a substance is defined as the saturation pressure above a solid or liquid substance and is determined at various temperatures (in Kelvin). The methods used are: the dynamic method (Cottrell's method), the static method, the isoteniscope Method, the effusion method: vapour pressure balance, the effusion method: Knudsen cell, the effusion method: isothermal thermogravimetry, the gas saturation method and the spinning rotor method. The vapour pressure from any of the preceding methods should be determined for at least two temperatures. Three or more are preferred in the range 0 to 50°C, in order to check the linearity of the vapour pressure curve. In case of Effusion methods and Gas saturation method, 120 to 150 °C is recommended for the measuring temperature range instead of 0 to 50°C The OECD Guidelines for the Testing of Chemicals are a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of new and existing chemical substances, chemical preparations and chemical mixtures. They are a basic set of tools used primarily in regulatory safety testing and subsequent chemical and chemical product notification and chemical registration. In addition, they can also be used for the selection and ranking of candidate chemicals during the development