Obesity, Inflammation and Cancer (Energy Balance and Cancer Book 7)

In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area. Front Matter....Pages i-xiii Obesity, Inflammation, and Insulin Resistance....Pages 1-23 Inflammasomes and Obesity....Pages 25-60 Uncoupling Obesity from Cancer: Bromodomain Co-regulators That Control Inflammatory Networks....Pages 61-81 Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer....Pages 83-98 Dietary Fats as Mediators of Obesity, Inflammation, and Colon Cancer....Pages 99-132 Inflammation, Obesity, Barrett’s Esophagus, and Esophageal Adenocarcinoma....Pages 133-145 Inflammation, Obesity, and Colon Cancer....Pages 147-180 Obesity, Inflammation, and Breast Cancer....Pages 181-217 Obesity, Inflammation, Nonalcoholic Fatty Liver Disease, and Hepatocellular Carcinoma....Pages 219-234 Obesity, Inflammation, and Prostate Cancer....Pages 235-256 Pharmacologic Interventions with NSAIDs....Pages 257-303 Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective....Pages 305-339 Natural Products as Anti-inflammatory Agents....Pages 341-361 Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms....Pages 363-379 Vascular Targeting of Adipose Tissue....Pages 381-400 Anti-inflammatory Effects of Exercise....Pages 401-424 Back Matter....Pages 425-433 In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area. Preface Obesity, Inflammation and Insulin Resistance Inflammasomes and Obesity Uncoupling Obesity from Cancer: Bromodomain Co-regulators that Control Inflammatory Networks Adipose Tissue Macrophages in Obesity, Inflammation and Cancer Dietary Fats as Mediators of Obesity, Inflammation and Colon Cancer Inflammation, Obesity, Barrett’s Esophagus and Esophageal Adenocarcinoma Obesity, Inflammation and Breast Cancer Obesity, Inflammation, Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma Obesity, Inflammation and Prostate Cancer Pharmacologic Interventions With NSAIDs Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective Natural Products as Anti-inflammatory Agents Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms Vascular Targeting of Adipose Tissue Anti-Inflammatory Effects of Exercise Index.