Obesity, Fatty Liver and Liver Cancer (Advances in Experimental Medicine and Biology, 1061)

This volume covers a state-of-the-art illustration of recent discoveries concerning obesity-related fatty liver diseases and liver cancer. The contents are extensive and comprehensive. It brings important topics in the field all together under one umbrella, from epidemiology and etiology, molecular pathogenesis, cellular biology, epigenetics, immunology, microbiology, animal models to therapeutic approaches and treatments. All the book contributors are leading experts in the field. It will appeal to researchers, clinicians and graduate students in obesity, fatty liver diseases, GI/Liver cancer field. It may also yield benefits for pharmaceutical companies with regard to drug discovery. Front Matter ....Pages i-xii Introduction (Chi Chun Wong, Jun Yu)....Pages 1-2 Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC (Ken Liu, Geoffrey W. McCaughan)....Pages 3-18 Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease (Geoffrey C. Farrell, Fahrettin Haczeyni, Shivakumar Chitturi)....Pages 19-44 Chemokines and Chemokine Receptors in the Development of NAFLD (Yoon-Seok Roh, Ekihiro Seki)....Pages 45-53 NAFLD Related-HCC: The Relationship with Metabolic Disorders (Xiang Zhang)....Pages 55-62 Hepatocellular Carcinoma in Obesity: Finding a Needle in the Haystack? (György Baffy)....Pages 63-77 Dysregulated Epigenetic Modifications in the Pathogenesis of NAFLD-HCC (Fung Zhao)....Pages 79-93 The Influence of Gut Microbial Metabolism on the Development and Progression of Non-alcoholic Fatty Liver Disease (Wei Jia, Cynthia Rajani)....Pages 95-110 Microbiota, Obesity and NAFLD (Louis H. S. Lau, Sunny H. Wong)....Pages 111-125 Autophagy, NAFLD and NAFLD-Related HCC (William K. K. Wu, Lin Zhang, Matthew T. V. Chan)....Pages 127-138 Animal Models of Non-alcoholic Fatty Liver Diseases and Its Associated Liver Cancer (Jennie Ka Ching Lau, Xiang Zhang, Jun Yu)....Pages 139-147 Current Prevention and Treatment Options for NAFLD (Vincent Wai-Sun Wong)....Pages 149-157