Nutrigenetics : Applying the Science of Personal Nutrition

__Nutrigenetics: Applying the Science of Personal Nutrition__ provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans. This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease. A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests. * Comprehensive coverage of the emerging science of nutritional genetics and its promise for individually tailored nutrition guidance * Presents practical examples to enhance comprehension and spur additional research * Offers a logical progression from what nutrigenetics is, to its possibilities in enhancing health Front Cover......Page 1 Nutrigenetics: Applying the Science of Personal Nutrition ......Page 4 Copyright......Page 5 Foreword......Page 7 Contents......Page 8 Preface......Page 10 1.1 LIFE IS NOT FAIR......Page 14 1.2 A GENETIC FRAMEWORK FOR NUTRITION DECISIONS ......Page 22 SUMMARY AND SEGUE TO THE NEXT CHAPTER......Page 26 References......Page 27 CHAPTER 2 - How Genetic Transmission Works ......Page 30 2.1 THE MOLECULAR STAGE......Page 31 2.2 INHERITANCE......Page 42 2.3 MOLECULAR EFFECTS OF GENETIC VARIATION......Page 53 References......Page 64 ABSTRACT ......Page 70 3.1 WHEN OUR ANCESTORS COULD STILL MAKE THEIR OWN VITAMINS ......Page 71 3.2 RECENT EVOLUTION OF GENETIC DIFFERENCES ......Page 75 3.3 MECHANISMS OF EVOLUTIONARY ADAPTATION ......Page 80 3.4 PROTECTION AGAINST INFECTIONS ......Page 91 3.5 THE GENETICS OF TASTE AND SMELL ......Page 95 3.6 GENDER DIFFERENCES ......Page 105 SUMMARY AND SEGUE TO THE NEXT CHAPTER ......Page 107 References......Page 108 ABSTRACT ......Page 116 4.1 IF SOMETHING CAN GO WRONG IT WILL ......Page 117 4.2 PROTEINS AND AMINO ACIDS ......Page 122 4.3 FATS ......Page 129 4.4 STEROLS ......Page 140 4.5 CARBOHYDRATES ......Page 143 4.6 ALCOHOLS ......Page 155 4.7 MINERALS ......Page 157 4.8 TRACE ELEMENTS ......Page 167 4.9 VITAMINS ......Page 179 SUMMARY AND SEGUE TO THE NEXT CHAPTER......Page 220 References......Page 221 5.1 GOOD NUTRITION MEANS DIFFERENT THINGS FOR DIFFERENT PEOPLE......Page 236 5.2 IT STARTS RIGHT AT THE BEGINNING-PRECONCEPTUAL AND PRENATAL NUTRITION......Page 237 5.3 BOOSTING COGNITIVE DEVELOPMENT OF INFANTS ......Page 241 5.4 CANCER......Page 242 5.5 DIABETES......Page 252 5.6 HEART DISEASE......Page 254 5.7 THROMBOEMBOLISM......Page 258 5.8 ASTHMA AND ALLERGIES......Page 260 5.9 GOUT......Page 262 5.10 THOSE CLINGY LOVE HANDLES......Page 266 5.11 FATTY LIVER DISEASE......Page 273 5.12 BONE HEALTH......Page 275 References......Page 277 ABSTRACT ......Page 286 6.1 TOOLS FOR NUTRIGENETIC RESEARCH AND PRACTICE ......Page 287 6.2 IN VITRO AND ANIMAL MODELS......Page 288 6.3 NUTRIGENETIC STUDIES IN HUMANS ......Page 294 6.4 MOST FIRST REPORTS OF NUTRIGENETIC INTERACTIONS ARE FALSE ......Page 308 SUMMARY AND SEGUE TO THE NEXT CHAPTER ......Page 315 References......Page 316 ABSTRACT......Page 320 7.2 PERSONAL NUTRITION......Page 321 7.4 FOCUS ON THE WEAKER LINK......Page 337 7.5 LEVERAGING NUTRIGENETIC CONCEPTS IN RESEARCH ......Page 341 References......Page 344 CHAPTER 8 - Keeping Genetic Information Safe ......Page 348 8.2 KEY LEGAL TERMS AND CONCEPTS FOR UNDERSTANDING GENETIC INFORMATION......Page 349 8.3 THE LEGAL REGIME AND LAWS RELATING TO GENETIC INFORMATION......Page 354 8.4 PATIENT RIGHTS......Page 359 8.5 DUTIES OF MEDICAL PROVIDERS......Page 362 SUMMARY......Page 365 References......Page 366 Genome Glossary......Page 368 DATABASES......Page 378 GENETIC SOFTWARE PACKAGES......Page 379 References......Page 380 Index......Page 382

Nutrigenetics: Applying the Science of Personal Nutrition provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans.

This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease.

A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests.

• Comprehensive coverage of the emerging science of nutritional genetics and its promise for individually tailored nutrition guidance
• Presents practical examples to enhance comprehension and spur additional research
• Offers a logical progression from what nutrigenetics is, to its possibilities in enhancing health

Nutrigenetics: Applying the Science of Personal Nutrition provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans. This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease. A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests. Comprehensive coverage of the emerging science of nutritional genetics and its promise for individually tailored nutrition guidancePresents practical examples to enhance comprehension and spur additional researchOffers a logical progression from what nutrigenetics is, to its possibilities in enhancing health -- Source other than Library of Congress