Nucleic Acid Therapeutics In Cancer (cancer Drug Discovery And Development)

The development of effectively targeted and efficiently delivered nucleic acids promises important advances in the diagnosis and treatment of human malignancies. In Nucleic Acid Therapeutics in Cancer, leading researchers, academic physicians, and clinicians clearly and succinctly review the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting methods and specific clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically. Concise yet highly readable, Nucleic Acid Therapeutics in Cancer offers those who require a cutting-edge critical synthesis not only a state-of-the-art account of this promising field, but also an illuminating introduction to their emerging therapeutic uses. Antisense methodology / Fritz Eckstein Nucleic acid therapeutics / Alan M. Gewirtz Targeted genome modification via triple helix formation / Faye A. Rogers and Peter M. Glazer Therapeutic applications of ribozymes / John J. Rossi Use of catalytic DNA in target validation and therapeutics / Lun-Quan Sun Targeted destruction of small, stable RNAs / David A. Dunbar and Susan J. Baserga Mechanism of action of antisense RNA in eukaryotic cells / Zuo Zhang and Gordon G. Carmichael The transport of oligonucleotides into cells / R.L. Juliano Peptide-mediated delivery of antisense oligonucleotides and related material / Eric Vivås, Jean Philippe Richard and Bernard Lebleu Molecular vectors for gene delivery to cancer cells / Guy Zuber ... [et al.] Considerations on the design of antisense oligonucleotides / Rosel Kretschmer-Kazemi Far, Jens Warnecke and Georg Sczakiel Identification of hybridization accessible sequence in messenger RNA / Lida K. Gifford, Ponzy Lu, and Alan M. Gewirtz Nucleic acids as gene targeting therapeutics / Joanna B. Opalinska and Susan E. Shetzline LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen) / C.A. Stein ... [et al.] Antisense protein kinase A-RI restores normal signal transduction signatures to inhibit tumor growth / Yoon S. Cho-Chung. A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically. The original concept for antisense methodology for the sequence-dependent inhibition of gene expression was remarkably simple.