Novel Frontiers In The Production Of Compounds For Biomedical Use (focus On Biotechnology, Volume 1)

The present book entitled “Novel Frontiers in the Production of Compounds for Biomedical Uses” can perhaps be placed in its best perspective by the Shakespearean character in The Tempest who exclaimed" What’s past is prologue”. Indeed, this compilation of some of the outstanding presentations in the field of biomedicine made at th the 9 European Congress on Biotechnology (Brussels, Belgium, July 11-15, 1999) not only reflects the achievements of the recent past, but provides a privileged glimpse of the biotechnology that is emerging in the first decade of the new Millennium. It is becoming increasingly apparent that biotechnology is offering biomedicine novel approaches and solutions to develop a sorely needed new generation of biopharmaceuticals. This is all the more necessary because in recent years, new diseases have emerged with extraordinary lethality in all corners of the globe, while age-related chronic illnesses have filled the gap wherever biomedicine has made successful inroads. The rise of antibiotic resistance also poses major threats to public health. Thus, as disease patterns evolve, the rational development of new drugs is becoming urgent, not only for the clinical outcome of patients, but also in optimising the allocation of scarce health care resources through the use of cost-effective productions methods. It is in response to all these challenges that biotechnology offers new strategies that go beyond the more traditional approaches. By the mid-1990’s, the number of recombinant products approved annually for therapeutic use reached double digits. With the advent of the genomics revolution. The Genomics Approach: Is it Really the Solution?....Pages 15-22 The Contribution of Genomics to the Discovery of New Antibiotics....Pages 23-31 The Antibiotic Gallidermin-Evolution of a Production Process....Pages 35-55 Resistance to β-Lactams, a Self-Regenerating Problem....Pages 57-83 Resistance to aminoglycoside Antibiotics: Function meets structure....Pages 85-98 The Genetics and Biochemistry of Resistance to Glycopeptide Antibiotics....Pages 99-115 β-Lactamases, an Old but Ever Renascent Problem....Pages 117-129 Metabolic Flux Analysis in Streptomyces Coelicolor: Effect of nitrogen source ....Pages 131-145 Metabolic Engineering of the Lysine Pathway for β-Lactam Overproduction in Penicillium Chrysogenum ....Pages 147-159 Glycosylation of Antibiotics and Other Agents from Actinomycetes....Pages 161-168 Enzymatic Synthesis of Amoxicillin....Pages 169-192 New Recombinant Bi- and Trispecific Antibody Derivatives....Pages 195-208 Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied....Pages 209-216 Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals....Pages 219-248 Development of Bioprocesses for the Generation of Anti-Inflammatory, Anti-Viral and Anti-Leukaemic Agents....Pages 249-265 Apoptosis and Bioprocess Technology....Pages 267-275 Gram-Positive Bacteria as Host Cells for Heterologous Production of Biopharmaceuticals....Pages 277-300 Multiple Pathways of Exoprotein Secretion in Gram-Negative Bacteria....Pages 301-311 Alteration of Metabolic Flux Distributions in Recombinant Escherichia Coli in Response to Heterologous Protein Production....Pages 313-337 Dynamics of Proteolysis and its Influence on the Accumulation of Intracellular Recombinant Protein....Pages 339-347 The Impact of Transgenesis and Cloning on Cell and Organ Xenotransplantation to Humans....Pages 351-363 Reinforced Bioartificial Skin in the Form of Collagen Sponge and Threads....Pages 365-380 Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis....Pages 383-399 Cell Immobilisation of Taxus Media....Pages 401-407 The Role of Prebiotics in Human Gut Microbiology....Pages 411-428 The Influence of Intestinal Microflora on Mucosal and Systemic Immune Responses....Pages 429-445

This book presents a selection of the most recent approaches for the production of novel biotechnological compounds for biomedical applications. In order to better focus on the challenges at hand, the Editors have striven to adopt an integrative approach by selecting contributions linking genomics with bacterial resistance, antibiotics with improved production strategies, optimised production approaches with chemical development programs, chemical modifications with new antibody derivatives and biomaterials, the relation between bioartificial organs and xenotransplantation, apoptosis and process biotechnology, etc. The different chapters provide an interesting overview of the current state of the art in the development of truly novel compounds for biomedical application using recombinant DNA approaches.
This book will be of interest to academic and industrial scientists dealing with biomedical sciences and for teachers who want to be informed about the latest developments in the field.

Presents a selection of different approaches for the production of novel biotechnological compounds for biomedical applications. This book includes contributions linking genomics with bacterial resistance, antibiotics with improved production strategies, and optimised production approaches with chemical development programs. This work presents a selection of approaches for the production of novel biotechnological compounds for biomedical applications. The different chapters provide an overview of the development of truly novel compounds for biomedical application using recombinant DNA approaches Antimicrobial drug discovery began with the identification of natural products that had the ability to kill bacteria in agar-filled Petri dishes.