Novel Chemotherapeutic Agents: Preactivation In The Treatment Of Cancer And Aids (medical Intelligence Unit)

This book is about a discovery termed "preactivation" that is considered a major breakthrough in photodynamic therapy and in drug development. The process of preactivation generates previously unknown chemotherapeutic agents that are not only effective against malignancies and viral infections, but are also easily tolerated. Front Matter....Pages i-xiii Challenges and Opportunities in New Drug Development....Pages 1-13 Preactivation-Discovery and Biological Effects of Novel Chemotherapeutic Agents....Pages 15-51 Photochemistry and Photophysics of Merocyanine 540....Pages 53-107 Preclinical Studies of Preactivated Merocyanine 540 and Merodantoin....Pages 109-144 The Role of Topoisomerases and Apoptosis in the Mechanism of Action of Preactivated Compounds....Pages 145-184 Modulation of Oncogenes with Preactivated Compounds....Pages 185-202 Epilogue....Pages 203-207 Back Matter....Pages 209-212