Novel Approaches to Treatment of Osteoporosis (Ernst Schering Foundation Symposium Proceedings, 25)

Osteoporosis affects a growing number of the population. Current treatments are based on prevention of further bone loss after the condition is diagnosed, often because a fracture has occurred. Treatments in the future will aim at healing osteoporosis by improving bone mass and quality. This book describes novel discoveries and research which will allow bone to be restored after it has been lost. Front Matter....Pages I-XIII The Advantages and Limitations of Cell Culture as a Model of Bone Formation....Pages 1-42 The Identification and Isolation of Cells of the Osteoblast Lineage in Cultures of Adult Human Bone-Derived Cells by Dual Labeling with the Monoclonal Antibodies STRO-1 and B4-78....Pages 43-59 Apoptosis in Bone Cells....Pages 61-82 Genetics in Osteoporosis....Pages 83-101 The Regulation of Bone Cell Differentiation and Proliferation by Transcription Factors....Pages 103-121 Transgenic and Gene Knock-Out Animals in Skeletal Research....Pages 123-155 Mechanotransduction: An Inevitable Process for Skeletal Maintenance....Pages 157-177 The Regulation of Gene Expression in Bone by Mechanical Loading....Pages 179-198 Amplification of the Osteogenic Stimulus of Load-Bearing as a Logical Therapy for the Treatment and Prevention of Osteoporosis....Pages 199-209 Novel Aspects of Parathyroid Hormone/Parathyroid Hormone-Related Protein Hormone-Receptor Interactions....Pages 211-225 Bone Morphogenetic Proteins: Role, Modes of Action and Potential Significance in Osteoporosis....Pages 227-260 Back Matter....Pages 261-264