Non-opioid analgesics in the treatment of acute pain : Johannesbergs Slott, Sweden, March 14th, 1996

Dipyrone is widely acknowledged to be an effective antipyretic analgesic with an additional intrinsic spasmolytic activity. It has stood the test of time over the last 75 years in many clinical settings throughout the world. Some 20 years ago, however, concern arose over the implications of isolat­ ed reports of agranulocytosis following use of dipyrone. Based on these initial cases the Swedish authorities ordered the withdrawal of the drug from the market. Subsequently, dipyrone has been subjected to extensive comparative epidemiological and clinical studies. The results of these in­ vestigations have allayed the earlier concerns and have shown dipyrone to be a versatile analgesic drug with an overall risk of serious adverse events lower than most other non-opioid analgesics. Based on these results, the Swedish authorities (Lakemedelsverket) have approved the reintroduc­ tion of dipyrone to clinical use as a valuable contribution to pain treat­ ment. In connection with this further milestone in the story of the drug, a symposium was held in Stockholm on March 14, 1996, under the chairman­ ship of Professor N. Rawal to review the current understanding of the ac­ tion, efficacy and safety of dipyrone. The highlights of this Hoechst symposium emphasize particularly the therapeutic basis for the use of dipyrone in the modern treatment of acute post-operative pain. 9 Mode of action of dipyrone Professor K. Brune, M. D. Erlangen, Germany Most non-opioid analgesic drugs are inhibitors of cydo-oxygenase, the en­ zyme catalysing the formation of prostaglandins (PGs). Dipyrone is widely acknowledged to be an effective antipyretic analgesic with an additional intrinsic spasmolytic activity. It has stood the test of time over the last 75 years in many clinical settings throughout the world. Some 20 years ago, however, concern arose over the implications of isolatƯ ed reports of agranulocytosis following use of dipyrone. Based on these initial cases the Swedish authorities ordered the withdrawal of the drug from the market. Subsequently, dipyrone has been subjected to extensive comparative epidemiological and clinical studies. The results of these inƯ vestigations have allayed the earlier concerns and have shown dipyrone to be a versatile analgesic drug with an overall risk of serious adverse events lower than most other non-opioid analgesics. Based on these results, the Swedish authorities (Lakemedelsverket) have approved the reintroducƯ tion of dipyrone to clinical use as a valuable contribution to pain treatƯ ment. In connection with this further milestone in the story of the drug, a symposium was held in Stockholm on March 14, 1996, under the chairmanƯ ship of Professor N. Rawal to review the current understanding of the acƯ tion, efficacy and safety of dipyrone. The highlights of this Hoechst symposium emphasize particularly the therapeutic basis for the use of dipyrone in the modern treatment of acute post-operative pain. 9 Mode of action of dipyrone Professor K. Brune, M.D. Erlangen, Germany Most non-opioid analgesic drugs are inhibitors of cydo-oxygenase, the enƯ zyme catalysing the formation of prostaglandins (PGs) Front Matter....Pages 1-5 Introduction....Pages 7-7 Mode of action of dipyrone....Pages 9-10 Clinical pharmacokinetics of dipyrone and its metabolites....Pages 11-12 Dipyrone in acute postoperative and colic pain....Pages 13-14 Non-opioid analgesics in the treatment of acute pain....Pages 15-16 Comparative safety of analgesics....Pages 17-18 Routines, practice and needs for analgesics in out-patient surgery in Sweden....Pages 19-20 Perspectives....Pages 21-21