Non-Neoplastic Hematologic Disorders - A Quick Review of Modern Diagnostic and Therapeutic Approaches (Oct 25, 2024)_(303162372X)_(Springer).pdf

In the current digital era with the exponential growth of medical knowledge, voluminous textbooks have gradually been replaced by the pocketbooks with tables, figures, images, and e-links to digital book versions with supplemental materials available online. The advent of novel next-generation sequencing (NGS) and multi-omics single cell methods have uncovered causative molecular mechanisms in most of the known non-neoplastic hematologic disorders. There is an urgent need for a concise and up-to-date handbook focused on non-malignant hematology. The book describes characteristic clinical features and state-of-the-art diagnostic approaches of non-neoplastic hematologic disorders. It introduces modern molecular biomarkers with enormous diagnostic and prognostic value and novel targeted gene therapy. Differential diagnosis also includes relevant hematologic malignancies that could represent diagnostic pitfalls. Chapters include take home points for each disorder in concise and easy memorable manner. The book also provides diagnostic algorithms, novel prognostic and predictive factors, up-to-date treatment options, clinically relevant molecular signatures, and ongoing promising clinical trials if available. There are more than 100 questions and answers with comments on laboratory values, updated cytogenetic and mutational profiles. Non-Neoplastic Hematologic Disorders: A Quick Review of Modern Diagnostic and Therapeutic Approaches provides concise clinical and laboratory information about most common non-neoplastic hematologic disorder for practicing hematologists, oncologists, hematopathologists, molecular pathologists, internal medicine specialists, pediatricians, research nurses, nurse practitioners, and trainees at all levels. Preface Contents Contributors Part I: Benign Disorders of White Blood Cells 1: Benign Neutrophilic Disorders Introduction Pathogenesis Diagnosis Neutrophilia Neutropenia Differential Diagnosis Neutrophilia Neutropenia Prognosis Treatment Promising Clinical Study References 2: Benign Eosinophil Disorders Introduction Pathogenesis Diagnosis Differential Diagnosis Treatment Prognosis References 3: Benign Monocytic Disorders Introduction Pathogenesis Diagnosis Differential Diagnosis Prognosis Treatment Promising Clinical Studies References 4: Benign Basophil and Mast Cell Disorders Basophils Introduction Pathophysiology Diagnosis Differential Diagnosis Treatment Mast Cells Introduction Pathophysiology Diagnosis Differential Diagnosis Prognosis Treatment Promising Clinical Studies References 5: Benign Lymphocytic Disorders Introduction Pathogenesis Diagnosis Peripheral Blood Smear Review Flow Cytome