Non-coding RNAs in Colorectal Cancer (Advances in Experimental Medicine and Biology Book 937)

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology. Introduction.-part I Non-coding Rnas: Biology And Implications In Colorectal Cancer Pathogenesis.-non-coding Rnas: Classification, Biology And Functioning.-involvement Of Non-coding Rnas In Hallmarks And Key Signaling Pathways Of Colorectal Cancer.-micrornas And Inflammation In Colorectal Cancer -- Interplay Between Transcription Factors And Micrornas Regulating Epithelial-mesenchymal Transitions In Colorectal Cancer -- Non-coding Rnas Functioning In Colorectal Cancer Stem Cells -- Microrna Methylation In Colorectal Cancer -- Polymorphisms In Non-coding Rna Genes And Their Targets Sites As Risk Factors Of Sporadic Colorectal Cancer. Part Ii Non-coding Rnas: New Class Of Biomarkers In Colorectal Cancer -- Non-coding Rnas As Biomarkers For Colorectal Cancer Screening And Early Detection -- Circulating Non-coding Rnas As Biomarkers In Colorectal Cancer -- Non-coding Rnas Enabling Prognostic Stratification And Prediction Of Therapeutic Response In Colorectal Cancer Patients -- Part Iii Non-coding Rnas: Therapeutic Targets And Colorectal Cancer Therapeutics -- Involvement Of Non-coding Rnas In Chemo- And Radioresistance Of Colorectal Cancer -- Non-coding Rnas: Therapeutic Strategies And Delivery Systems -- Micrornas As Therapeutic Targets And Colorectal Cancer Therapeutics -- Summary -- Index. Ondřej Slabý, George A. Calin, Editors. Includes Bibliographical References And Index. Front Matter....Pages i-viii Front Matter....Pages 1-1 Non-coding RNAs: Classification, Biology and Functioning....Pages 3-17 Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer....Pages 19-51 MicroRNAs and Inflammation in Colorectal Cancer....Pages 53-69 Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer....Pages 71-92 Non-coding RNAs Functioning in Colorectal Cancer Stem Cells....Pages 93-108 MicroRNA Methylation in Colorectal Cancer....Pages 109-122 Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer....Pages 123-149 Front Matter....Pages 151-151 Non-coding RNAs as Biomarkers for Colorectal Cancer Screening and Early Detection....Pages 153-170 Circulating Non-coding RNA as Biomarkers in Colorectal Cancer....Pages 171-181 Non-coding RNAs Enabling Prognostic Stratification and Prediction of Therapeutic Response in Colorectal Cancer Patients....Pages 183-204 Front Matter....Pages 205-205 Involvement of Non-coding RNAs in Chemo- and Radioresistance of Colorectal Cancer....Pages 207-228 Non-coding RNAs: Therapeutic Strategies and Delivery Systems....Pages 229-237 MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics....Pages 239-247 Back Matter....Pages 249-252