Nitric Oxide (NO) and Cancer: Prognosis, Prevention, and Therapy (Cancer Drug Discovery and Development)

The Nobel Prize in Physiology and Medicine was awarded in 1998 to Doctors Furchgott, Ignarro, and Murad for their discoveries concerning "Nitric oxide (NO) as a signaling molecule in the cardiovascular system." NO-inducing cell signaling events within the cell producing it and the diffusibility to NO in other cells have led to the discovery of many other physiological functions in many different types of cells including cancer. Noteworthy, nitroglycerin that has been used for the treatment of chest pain and associated cardiovascular diseases is currently being investigated for its therapeutic effect in clinical studies in patients with cancer. Further, several NO donor compounds have shown, in preclinical studies, anti-tumoral chemopreventive and therapeutic activities. "Nitric Oxide and Cancer: Prognosis, Prevention and Therapy", edited by Benjamin Bonavida, Ph.D., reviews several novel applications of NO in cancer, a new field that has rapidly gained credibility and understanding at the biochemical and molecular levels. The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO. Front Matter....Pages i-xx Front Matter....Pages 1-1 Nitric Oxide and Cancer: An Overview....Pages 3-20 Front Matter....Pages 21-21 A Role for eNOS in Oncogenic Ras-Driven Cancer....Pages 23-38 Dual Role of Nitric Oxide in Cancer Biology....Pages 39-57 Nitric Oxide Expression in Cancer....Pages 59-82 Front Matter....Pages 83-83 S-Nitrosylation – How Cancer Cells Say NO to Cell Death....Pages 85-102 Cytotoxic and Protective Activity of Nitric Oxide in Cancers....Pages 103-132 Cytotoxic/Protective Activity of Nitric Oxide in Cancer....Pages 133-145 Nitric Oxide and Life or Death of Human Leukemia Cells....Pages 147-167 Inhibition of Apoptosis by Endogenous Nitric Oxide in Chronic Lymphocytic Leukaemia....Pages 169-185 Front Matter....Pages 187-187 Nitric Oxide: A Rate-Limiting Factor for Metastases Development....Pages 189-207 Nitric Oxide Inhibits Tumor Cell Metastasis via Dysregulation of the NF-κB/Snail/RKIP Loop....Pages 209-233 Front Matter....Pages 235-235 Sensitizing Effect of Nitric Oxide to Cytotoxic Stimuli....Pages 237-252 Nitric Oxide Is a Promising Enhancer for Cancer Therapy....Pages 253-263 Role of Nitric Oxide for Modulation of Cancer Therapy Resistance....Pages 265-282 Breaking Resistance: Role of Nitric Oxide in the Sensitization of Cancer Cells to Chemo- and immunotherapy....Pages 283-290 Front Matter....Pages 291-291 Prognostic Significance of iNOS in Human Melanoma....Pages 293-307 Prognostic Significance of iNOS in Hepatocellular Carcinoma....Pages 309-328 Prognostic Significance of iNOS in Esophageal Cancer....Pages 329-340 Prognostic Significance of Nitrative DNA Damage in Infection- and Inflammation-Related Carcinogenesis....Pages 341-357 Front Matter....Pages 359-359 Nitric Oxide-Releasing Molecules for Cancer Therapy and Chemoprevention....Pages 361-385 Front Matter....Pages 359-359 Nitric Oxide: Monotherapy or Sensitiser to Conventional Cancer Treatments?....Pages 387-417 Therapeutic Applications of Nitric Oxide for Malignant Tumor in Animal Models and Human Studies....Pages 419-441 ( S,R )-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid–Nitric Oxide (GIT-27NO) – New Dress for Nitric Oxide Mission....Pages 443-457 Nitric Oxide Donors Are a New Class of Anti-cancer Therapeutics for the Reversal of Resistance and Inhibition of Metastasis....Pages 459-477 Role of Inducible Nitric Oxide Synthase (iNOS) in Regulation of Nitric Oxide (NO) Production and Stabilization of HIF-1α: Potential Role of Se-Methylselenocysteine (MSC), an Antioxidant Multi-targeted Small Molecule....Pages 479-488 Back Matter....Pages 489-513 "The Nobel Prize in Physiology And Medicine was Awarded in 1998 to Doctors Furchgott, Ignarro, and Murad for their Discoveries concerning "Nitric oxide (N0) as A signaling molecule in the cardiovascular system." No-inducing cell signaling events within the cell producing it and the diffusibility to NO in other cells have led to the discovery of many other physiological functions in many different types of cells including cancer. Noteworthy, nitroglycerin that has been used for the treatment of chest pain and associated cardiovascular diseases is currently being investigated for its therapeutic effect in clinical studies in patients with cancer. Further, several NO donor compounds have shown, in preclinical studies, anti-tumoral chemopreventive and therapeutic activities." ""Nitric Oxide and Cancer: Prognosis, Prevention and Therapy", edited by Benjamin Bonavida, Ph.D., reviews several novel applications of NO in cancer, a new field that has rapidly gained credibility and understanding at the biochemical and molecular levels. The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO" "Part I: General Overview. Part II: Nitric Oxide in the Pathogenesis of Cancer (3 contributions). Part III: Dual Roles of Nitric Oxide to Protecting or Inducing Cell Death (5 contributions). Part IV: Role of Nitric Oxide in Metastasis (2 contributions). Part V: Nitric Oxide as a Sensitizing Agent for Chemo-radio-immunotherapies (4 contributions). Part VI: Prognostic Significance of NOS and NO (4 contributions). Part VII: Therapeutic Applications of Nitric Oxide (6 contributions)."--BOOK JACKET The Nobel Prize in Physiology and Medicine was awarded in 1998 to Doctors Furchgott, Ignarro, and Murad for their discoveries concerning "Nitric oxide (NO) as a signaling molecule in the cardiovascular system." NO-inducing cell signaling events within the cell producing it and the diffusibility to NO in other cells have led to the discovery of many other physiological functions in many different types of cells including cancer. Noteworthy, nitroglycerin that has been used for the treatment of chest pain and associated cardiovascular diseases is currently being investigated for its therapeutic effect in clinical studies in patients with cancer. Further, several NO donor compounds have shown, in preclinical studies, anti-tumoral chemopreventive and therapeutic activities. "Nitric Oxide and Cancer: Prognosis, Prevention and Therapy", edited by Benjamin Bonavida, Ph. D., reviews several novel applications of NO in cancer, a new field that has rapidly gained credibility and understanding at the biochemical and molecular levels. The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.