نیکوتین در روان‌پزشکی: روان‌پاتولوژی و درمان‌های نوظهور (عمل بالینی، شماره ۴۸)

Today, 25% of Americans smoke and 50% of smokers die from tobacco-related illnesses. Meanwhile, little attention has been given to implementing cessation therapies for our patients who smoke. Nicotine in Psychiatry: Psychopathology and Emerging Therapeutics examines this timely subject. The book's contributors, subject matter experts in the growing field of nicotine neurobiology andclinical pharmacology, cover the latest knowledge on -The pharmacokinetics and pharmacodynamics of nicotine -The effect of nicotinic receptors on the central nervous system (CNS), the recent advances made in understanding the normal function of these receptors, and how this knowledge transfers to the clinical treatment of many CNS disorders -Behavioral factors influencing the effects of nicotine and nicotine's addictive capacity -The association between smoking and specific mental disorders and the association between nicotine and mood -Clinical applications of nicotine as a potential therapeutic agent for a variety of disorders, such as attention deficit, Alzheimer's and Parkinson's diseases, epilepsy, inflammatory bowel disease, schizophrenia, and Tourette's syndrome -Nicotine replacement therapies and various smoking-cessation strategies This book makes fascinating reading for anyone interested in the recent tobacco public policy debates, as well as clinicians and researchers looking for current information on nicotine and its clinical applications.

Today, 25% of Americans smoke and 50% of smokers die from tobacco-related illnesses. Meanwhile, little attention has been given to implementing cessation therapies for our patients who smoke.

Nicotine in Psychiatry: Psychopathology and Emerging Therapeutics examines this timely subject. The book's contributors, subject matter experts in the growing field of nicotine neurobiology andclinical pharmacology, cover the latest knowledge on • The pharmacokinetics and pharmacodynamics of nicotine• The effect of nicotinic receptors on the central nervous system (CNS), the recent advances made in understanding the normal function of these receptors, and how this knowledge transfers to the clinical treatment of many CNS disorders• Behavioral factors influencing the effects of nicotine and nicotine's addictive capacity• The association between smoking and specific mental disorders and the association between nicotine and mood• Clinical applications of nicotine as a potential therapeutic agent for a variety of disorders, such as attention deficit, Alzheimer's and Parkinson's diseases, epilepsy, inflammatory bowel disease, schizophrenia, and Tourette's syndrome• Nicotine replacement therapies and various smoking-cessation strategies

This book makes fascinating reading for anyone interested in the recent tobacco public policy debates, as well as clinicians and researchers looking for current information on nicotine and its clinical applications.

Contents......Page 6 Contributors......Page 8 Introduction to the Clinical Practice Series......Page 12 Foreword......Page 14 Preface......Page 20 SECTION I: Background......Page 22 1 Neurobiology and Clinical Pathophysiology of Neuronal Nicotinic Acetylcholine Receptors......Page 24 2 Pharmacokinetics and Pharmacodynamics of Nicotine......Page 58 3 Behavioral Factors Influencing the Effects of Nicotine......Page 80 4 Addictive Capacity of Nicotine......Page 104 SECTION II: Clinical Applications......Page 130 5 Nicotine and Major Mental Disorders......Page 132 6 Smoking, Nicotine, and Mood......Page 152 7 Nicotinic Cholinergic Systems in Alzheimer’s and Parkinson’s Diseases......Page 170 8 Smoking, Nicotine, and Movement Disorders......Page 204 9 Nicotine Effects and Attention-Deficit/Hyperactivity Disorder......Page 224 10 Nicotine Replacement Therapies and Beyond......Page 236 11 Behavioral Treatment of Cigarette Smoking and Nicotine Dependence......Page 256 Afterword: Nicotine and Nicotinic Systems in Psychiatry: Past and Future......Page 274 A......Page 278 C......Page 281 D......Page 284 E......Page 285 H......Page 286 M......Page 287 N......Page 289 P......Page 293 R......Page 295 S......Page 296 T......Page 298 Z......Page 300 Although acetylcholine was identified as a peripheral neurotransmitter in the early part of the century, it was only in the late 1950s that evidence of neurotransmission within the central nervous system was produced by means of demonstration of cholinergic transmission at motor neuron-Renshaw cell synapses in the spinal cord (Curtis and Eccles 1958). This book examines the importance of nicotine and nicotinic pharmacology in psychiatry and neuroscience. The book's contributors, subject matter experts in the growing field of nicotine neurobiology and clinical pharmacology, compile the latest knowledge available on the basic science and clinical applications of nicotine.