Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy (Dermatology, Clinical and Basic Science)

Allergic contact dermatitis from nickel is a continuing health problem and its prevalence is increasing. It may occur in sensitized individuals following contact with nickel-containing items such as jewelry, zippers, buttons, and other objects; by nickel leaching from implants and prostheses; and following occupational exposures. Nickel and the Skin gives an extensive, updated review of new aspects, as well as previously discussed topics, covering material progress in the field of nickel hypersensitivity. It complements the mandate of the Nickel Producers Environmental Research Association, which is to promote the health and safety of those exposed to nickel or nickel containing products in the workplace and general environment. Ch. 1. Aspects Of Nickel Allergy : Epidemiology, Etiology, Immune Reactions, Prevention, And Therapy / Jurij J. Hostýnek -- Ch. 2. Nickel Allergic Hypersensitivity : Prevalence And Incidence By Country, Gender, Age, And Occupation / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 3. Oxidative Properties Of The Skin : A Determinant For Nickel Diffusion / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 4. Release Of Nickel Ion From The Metal And Its Alloys As Cause Of Nickel Allergy / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 5. Skin Absorption Of Nickel And Methods To Quantify Penetration / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 6. Diagnostic Testing For Nickel Allergic Hypersensitivity : Patch Testing Versus Lymphocyte Transformation Test / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 7. Orally Induced Tolerance To Nickel : The Role Of Oral Exposure (orthodontic Devices) In Preventing Sensitization / Jurij J. Hostýnek, Katherine E. Reagan, And Howard I. Maibach -- Ch. 8. Biochemical Aspects Of Nickel Hypersensitivity : Factors Determining Allergenic Action / Baldassarré Santucci, Emanuela Camera, And Mauro Picardo -- Ch. 9. Nickel Metal And Alloys / G. Norman Flint And C. Peter Cutler. Edited By Jurij J. Hostýnek, Howard I. Maibach. Includes Bibliographical References And Index. Allergic contact dermatitis from nickel is a continuing and increasing health problem. Nickel dermatitis may occur in sensitized individuals following contact with nickel-containing items such as jewelry, zippers, buttons, and other objects; by nickel leaching from implants and prostheses; and following occupational exposures. Although the most common of the health effects associated with exposure to nickel, the skin penetration of nickel and its compounds is poorly understood. Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy gives an extensive, updated review o Nickel is an allergen causing type I and type IV hypersensitivity, mediated by reagins and allergen-specific T lymphocytes. An extensive review of major topics and new topics, and covers material progress in the field of nickel hypersensitivity