Next Generation Antidepressants (Moving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders)

The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice. "The World Health Organization defines depression as one of the primary contributors to the global burden of disease and predicts it will become the second leading cause of death by the year 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs are mederately effective in certain patient populations; however, they have a number of limitations, including delayed onset of efficacy, treatment resistance and deleterious side effects. This book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This will be essential reading for all those involved in psychopharmacologic drug development, as well as for mental health clinicians seeking a preview of discoveries soon to influence their practice."--[Résumé de l'éditeur] This 2010 book looks at the future of mood-disorder research, covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities, and increasing understanding of genetic influences. Essential reading for everyone involved in psychopharmacology development, and mental health clinicians seeking a preview of discoveries soon to influence their practice. This text looks at the future of mood-disorder research, covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities, and increasing understanding of genetic influences-- Edited By Chad E. Beyer And Stephen M. Stahl. Includes Bibliographical References And Index.