New trends in the diagnosis and therapy of Non-Alzheimer's dementia : [presented at the 4th International Symposium of the Research Initiative EBEWE, held in October 13 to 15, 1995 in Vienna

This volume gives an overview of the present state of art on the classification, neuropathology, clinical presentation, neuropsychology, diagnosis, neuroimaging and therapeutic possibilities in non-Alzheimer’s dementias, an increasingly important group of CNS diseases, which account for 7 to 30% of dementing disorders in adults and aged subjects, and thus, represent the second most frequent cause of dementia after Alzheimer’s disease. The monograph provides the newest information for neurologists, psychiatrists, dementia research workers, dementia clinicians, neuropathologists, neurobiologists, and practicing physicians. Front Matter....Pages I-VIII Structural basis of dementia in neurodegenerative disorders....Pages 1-29 Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in Diffuse Lewy body disease, Pick’s disease, and Corticobasal Degeneration....Pages 31-46 The neuropathologic diagnostic criteria of frontal lobe dementia revisited. A study of ten consecutive cases....Pages 47-59 Cognitive deficits in non-Alzheimer’s degenerative diseases....Pages 61-71 The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared....Pages 73-101 Clinical features of frontal lobe dementia in comparison to Alzheimer’s disease....Pages 103-123 Frontal lobe dementia and motor neuron disease....Pages 125-132 Clinical and pathological characteristics of primary progressive aphasia and frontal dementia....Pages 133-141 MR-imaging of non-Alzheimer’s dementia....Pages 143-153 Functional imaging techniques in the diagnosis of non-Alzheimer dementias....Pages 155-167 Quantitative EEG in frontal lobe dementia....Pages 169-181 Vascular dementia: perfusional and metabolic disturbances and effects of therapy....Pages 183-191 The spectrum of depressive pseudo-dementia....Pages 193-203 Molecular biology of APO E alleles in Alzheimer’s and non-Alzheimer’s dementias....Pages 205-218 Transmissible cerebral amyloidosis....Pages 219-229 Human prion diseases....Pages 231-246 The survival response of mesencephalic dopaminergic neurons to the neurotrophins BDNF and NT-4 requires priming with serum: comparison with members of the TGF-β superfamily and characterization of the serum-free culture system....Pages 247-258 Tau protein and apolipoprotein E in CSF diagnostics of Alzheimer’s disease: impact on non Alzheimer’s dementia?....Pages 259-266 Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin ® ....Pages 267-273 Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides....Pages 275-275 Cerebrolysin ® protects neurons from ischemia-induced loss of microtubule — associated protein 2....Pages 276-276 The long-term effect of NGF, b-FGF and Cerebrolysin ® on the spatial memory after fimbria-fornix lesion in rats....Pages 277-277 The influence of Cerebrolysin ® and E021 on spatial navigation of young rats....Pages 278-278 Effects of Cerebrolysin ® on cytoskeletal proteins after focal ischemia in rats....Pages 279-279 The short-term influence of b-FGF, NGF and Cerebrolysin ® on the memory impaired after fimbria-fornix lesion....Pages 280-280 Brain tissue hydrolysate, Cerebrolysin ® , acts on presynaptic adenosine receptors in the rat hippocampus....Pages 281-281 Back Matter....Pages 283-288 Provides an overview of the state-of-art on the classification, neuropathology, clinical presentation, neuropsychology, diagnosis, neuroimaging and therapeutic possibilities in non-Alzheimer's dementias.