New Trends in Genetic Risk Assessment: Based on the Proceedings of the Fifth International Round Table of the Rhone-Poulenc Sante Foundation, Nice 1

New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages v-x Participants , Pages xi-xv Preface , Pages xvii-xviii , G. Jolles, A. Cordier Acknowledgements , Page xix , G. Jolies, A. Cordier 1 - The Role of Genotoxicity in Drug Safety Evaluation , Pages 3-12 , E. MOUSTACCHI Introduction , Pages 15-17 , A. SARASIN 2 - DNA Repair and Genetic Alterations , Pages 19-39 , M. RADMAN 3 - Molecular Approaches to the Detection of Germinal Mutations in Mammalian Organisms, Including Man , Pages 41-56 , H.W. MOHRENWEISER, E.W. BRANSCOMB 4 - Molecular Analysis of Genetic and Epigenetic Alterations in Human Cells , Pages 57-70 , A.R. LEHMANN, C.F. ARLETT, M. GEBARA, S.A. HARCOURT, M.R. JAMES, J.R. LAMB, W.J. MURIEL, H. STEINGRIMSDOTTIR 5 - Artificial Intelligence in the Study of the Structural Relationships Amongst Mutagens and Carcinogens , Pages 71-88 , H.S. ROSENKRANZ, G. KLOPMAN Genotoxicity and Covalent Binding. An Introduction , Pages 91-95 , G. DIRHEIMER 6 - Fluorimetric Analysis of DNA-strand Breakage and Repair Kinetics. Application to Radiotoxicology , Pages 97-108 , O. RIGAUD, H. MAGDELENAT 7 - Detection by 32 P-postlabelling of Carcinogen–DNA Adducts in Animals and Man , Pages 109-124 , D.H. PHILLIPS 8 - SOS Chromotest and the Use of Bacteria for the Detection and Diagnosis of Genotoxic Agents , Pages 125-136 , M. HOFNUNG, P. QUILLARDET, O. GOERLICH, E. TOUATI Introduction , Pages 139-143 , E. MOUSTACCHI 9 - Mutation at the hprt Locus in Human T-lymphocytes: In Vivo and In Vitro Studies , Pages 145-159 , R.J. ALBERTINI, JA NICKLAS, J.P. O'NEILL 10 - Mutagenicity and Clastogenicity Testing with Mouse Lymphoma Cells , Pages 161-174 , C.F. ARLETT, J. COLE, M.-C. DIOT, B.A. BRIDGES 11 - Measurement of Mutant Frequency to 6-Thioguanine Resistance in Circulating T-lymphocytes for Human Population Monitoring , Pages 175-203 , J. COLE, C.F. ARLETT, M.H.L GREEN, S.E. JAMES, L. HENDERSON, H. COLE, M. SALA-TREPAT, R. BENZI, M.L. PRICE, B.A. BRIDGES Introduction , Pages 207-209 , C. MELCION, A. CORDIER 12 - Specific Sites of Chromosomal Radiation-induced Rearrangements , Pages 211-224 , L. SABATIER, M. MULERIS, M. PRIEUR, W. AL ACHKAR, F. HOFFSCHIR, M. PROD'HOMME-RICOUL, M. GERBAULT-SEUREAU, E. VIEGAS-PEQUIGNOT, B. DUTRILLAUX 13 - Flow Cytometric Analysis and Sorting of Chromosomes , Pages 225-245 , M.A. VAN DILLA, P.N. DEAN, J.C. FUSCOE, J.W. GRAY, J.N. LUCAS, D.C. PETERS, B.J. TRASK, G.J. VAN DEN ENGH 14 - Flow Cytometric Detection of Micronuclei , Pages 247-260 , C. MELCION, A. CORDIER 15 - Induced Chromosome Aneuploidy: its Role in the Assessment of the Genetic Toxicology of Environmental Chemicals , Pages 261-296,296a,296b , J.M. PARRY, E.M. PARRY 16 - Assessment of Chemically-induced Aneuploidy: an Assay System Using a Mouse/Human Hybrid Cell Line , Pages 297-316 , R.S. ATHWAL, R. GUDI, S.S. SANDHU Introduction , Pages 319-322 , A. LEONARD 17 - Prospective Overview on Germ Cell Mutations in Mice , Pages 323-342 , U.H. EHUNG 18 - Flow Cytometric Analysis of Toxic Chemical-induced Alterations in Testicular Cell Kinetics and Sperm Chromatin Structure , Pages 343-365 , D.P. EVENSON Introduction , Pages 369-372 , F.J.C. ROE 19 - Reflections on the Declining Ability of the Salmonella Assay to Detect Rodent Carcinogens as Positive , Pages 373-387 , J. ASHBY 20 - Methods for Genetic Toxicology Testing Strategies , Pages 389-400 , D. BRUSICK 21 - New Approaches to Battery Selection and Interpretation , Pages 401-431 , H.S. ROSENKRANZ, F.K. ENNEVER 28 - Risk Assessment of Genotoxic Agents: Problems and Possible Solutions , Pages 433-448 , L. EHRENBERG 23 - Genetic Risk Estimation: Experience with Ionizing Radiation and its Relevance for Mutagenic Chemicals , Pages 449-477 , K. SANKARANARAYANAN Index , Pages 479-486