New Transcription Factors and their Role in Diabetes and its Therapy

This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity *Underscores the clinical relevance of transcription factors *Provides a valuable overview of the current status of the field Content: Preface Pages vii-viii List of contributors Pages ix-xii Chapter 1 Transcription factor genes in type 2 diabetes Review Article Pages 1-14 Michael N. Weedon, Andrew T. Hattersley, Timothy M. Frayling Chapter 2 PPAR γ , a key therapeutic target in the metabolic syndrome – unique insights derived from the study of human genetic variants Review Article Pages 15-41 Catherine S. Mitchell, Mark Gurnell Chapter 3 PPAR δ : Emerging therapeutic potential of novel agonists in lipid and glucose homeostasis Review Article Pages 43-62 Uwe Dressel, George E.O. Muscat Chapter 4 Liver X receptors as potential drug targets for diabetes and its disorders Review Article Pages 63-89,311-312 Knut R. Steffensen Chapter 5 SREBP-1c regulation of nutrient homeostasis and lipid accumulation Review Article Pages 91-113 Pascal Ferré, Delphine Eberlé, Bronwyn Hegarty, Fabienne Foufelle Chapter 6 The adipocyte and adipose tissue as endocrine organs: Impact on the insulin resistance phenotype Review Article Pages 115-141 Robert R. Henry, Susan A. Phillips, Sunder R. Mudaliar, Theodore P. Ciaraldi Chapter 7 FOXC2 in the adipocyte Review Article Pages 143-152,313 Sven Enerbäck Chapter 8 Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors Review Article Pages 153-171,314 Isabelle Gerin, Hyuk C. Cha, Ormond A. MacDougald Chapter 9 GATA proteins as molecular gatekeepers of adipogenesis Review Article Pages 173-185,315 Judy Tsai, Qiang Tong, Gökhan S. Hotamisligil Chapter 10 Forkhead proteins and the regulation of hepatic gene expression Review Article Pages 187-210,316-317 Andreas Barthel, Stephan Herzig, Dieter Schmoll Chapter 11 Disruption of CREB regulated of gene expression in diabetes Review Article Pages 211-231,318 Jane E.B. Reusch, Peter A. Watson, Subbiah Pugazhenthi Chapter 12 Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: Functional implications Review Article Pages 233-253 Jussi Pihlajamäki, Mary Elizabeth Patti Chapter 13 Hepatic CCAAT/enhancer binding protein β (C/EBP β ): engineer of diabetes, obesity, and inflammatory disease processes Review Article Pages 255-278,319 Jill M. Schroeder-Gloeckler, Shaikh Mizanoor Rahman, Jacob E. Friedman Chapter 14 Insulin resistance, inflammation, and the IKK/I κ B/NF- κ B pathway Review Article Pages 279-302,320-321 Bankim A. Bhatt, Robert M. O’Doherty Index Pages 303-309 The activation of nuclear receptors and DNA binding proteins serves as a final target for hormones and intracellular signaling pathways underlying many important physiological and metabolic pathways. Over the last 5-10 years, a new era of research has begun, arising from the application of molecular biology to the field of transcriptional regulation of metabolism and obesity. In addition, the application of transgenic and gene knockout technology to uncover the role of these transcription factors, and their potential application for therapeutic intervention, has led to new insights and broader understanding of the clinical relevance of these proteins in metabolic research.New Transcription Factors and Their Role in Diabetes and Its Therapy contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this volume provides a comprehensive look at several examples of how transcription factors may underlie the pathogenetic mechanisms of diabetes and obesity. This volume also provides a valuable overview of the status of the field as well as valuable information to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins provides the reader with the theoretical background to understand the strategies for new potential therapeutic targets and their applications to disease. This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity.

Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease.

*Applies molecular biology to transcriptional regulation of metabolism and obesity
*Underscores the clinical relevance of transcription factors
*Provides a valuable overview of the current status of the field