New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM (Advances in Predictive, Preventive and Personalised Medicine Book 3)

This book is intended to provide up-to-date and emerging information in the field of diabetes mellitus with a focus on preventive, predictive and personalized medicine. Front Matter....Pages i-xvii Global Figures Argue in Favour of Preventive Measures and Personalised Treatment to Optimise Inadequate Diabetes Care....Pages 1-13 Three Levels of Prediction, Prevention and Individualised Treatment Algorithms to Advance Diabetes Care: Integrative Approach....Pages 15-28 Diabetes Mellitus: New Challenges and Innovative Therapies....Pages 29-87 Identification of Biomarkers for Beta Cell Failure as Detection Tools for Predictive Screening in Type 2 Pre-diabetes....Pages 89-116 Endothelial Dysfunction in Diabetes: Role of Circulating Biomarkers as Potential Diagnostic and Prognostic Tools....Pages 117-146 Correction of Diabetes-Induced Endothelial Progenitor Dysfunction to Promote Retinal Vascular Repair....Pages 147-174 Oxidative Stress and Apoptotic Biomarkers in Diabetic Retinopathy....Pages 175-209 Diabetic Retinopathy: The Need for Predictive, Preventive and Personalized Approach to Management....Pages 211-232 The Role of Inflammatory Cytokines in Diabetic Nephropathy: Potential Use as Predictive Markers for Early Detection and Progression....Pages 233-263 Preventing Hyperglycemia and Tissue Injury in Diabetes: The Dynamic Role of 2,3 Indoleamine Dioxygenase (IDO) in Diabetes and Its Complications....Pages 265-282 An Integrative Approach to Chronic Wounds in Patients with Diabetes: PPPM in Action....Pages 283-321 Understanding Inflammation: The Key to Targeted Preventive Measures for Diabetes and Periodontitis....Pages 323-353 Cancer Predisposition in Diabetic Patients: Risk Assessment and Targeted Preventive Measures....Pages 355-370 Recognition of Individual Risks by Analysis of Subcellular Imaging Insights into Chromium Picolinate Therapy in Pre/Diabetes Care, Search into Its Safety and Opinion Controversy....Pages 371-387 Remote Control in Diabetes....Pages 389-398 Drug Delivery Systems for Predictive Medicine: Polymers as Tools for Advanced Applications....Pages 399-455 Back Matter....Pages 457-538 The writings of earliest civilizations reveal that diabetes mellitus has afflicted man for a very long time. Unfortunately, however, we are now experiencing a world-wide pandemic of the disease which has not been adequately addressed. Available evidence suggests that worldwide every 10 seconds one patient dies of diabetes and its severe complications. The outlook is even more bleak with the prediction of half of a billion diabetic patients by the year 2030. The cost-impact of the disease poses a major challenge for both developed and developing countries and their economies. Thus, it is high time to reconsider and revise the current strategies in diabetes care. Accordingly, a paradigm shift from reactive to perspective medicine has become a timely consideration. This shift is based on the concept of Predictive, Preventive and Personalized Medicine (PPPM). The rationale for PPPM relates to the recognition that prediction of persons at high risk for the disease (i.e., diabetes mellitus) should help devise strategies to prevent its target organ complications, and create effective treatments tailored to the individual patient, thereby reducing morbidity, and associated costs, and mortality. The current book entitled "New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM" is intended to serve as a reference source for researchers and the healthcare industry with a special emphasis on health promotion in the general population and help design innovative strategies to prevent the onset of diabetes mellitus and its secondary complications