New Strategies for Oral Immunization : International Symposium at the University of Alabama at Birmingham and Molecular Engineering Associates, Inc. Birmingham, AL, USA, March 21–22, 1988

Oral immunization has a fascinating and frequently successful history, yet it has been largely overshadowed by other immunization methods. Various vaccines that lead to the induction of antibodies in respiratory, gastrointestinal, and genitourinary tracts are currently under development, and others are in use for the immunization of animals as well as humans. This volume gives oral immunization the attention it deserves in light of recent methodological and technical advances in antigen delivery systems. Front Matter....Pages I-IX Front Matter....Pages 1-1 Oral Immunization: Past and Present....Pages 3-11 Overview of the Mucosal Immune System....Pages 13-25 Front Matter....Pages 27-27 Cholera Toxin and its Subunits as Potential Oral Adjuvants....Pages 29-33 Selective Delivery of Antigens by Recombinant Bacteria....Pages 35-49 Liposomes as Oral Adjuvants....Pages 51-58 Biodegradable Microspheres: Vaccine Delivery System for Oral Immunization....Pages 59-66 Front Matter....Pages 67-67 Introduction to Oral Immunization Against Viral Infections....Pages 69-72 Oral Immunization and Secretory Immunity to Viruses....Pages 73-81 Oral Immunization with Influenza Virus: Experimental and Clinical Studies....Pages 83-89 Immune Responses to Influenza Virus in Orally and Systemically Immunized Mice....Pages 91-99 Efficacy of Inactivated Influenza Vaccine Delivered by Oral Administration....Pages 101-106 The Systemic and Mucosal Immune Response of Humans to Influenza A Virus....Pages 107-116 Oral Immunization with Sendai Virus in Mice....Pages 117-122 Immunity to Rotaviruses....Pages 123-136 Rabies Oral Immunization....Pages 137-151 Front Matter....Pages 153-153 Induction of the Mucosal Immune Response....Pages 155-160 Systemic Immunization for the Induction of IgA Responses....Pages 161-168 Prevention of Invasive Bacterial Diseases by Immunization with Polysaccharide-Protein Conjugates....Pages 169-180 Protection Induced Against Acute Bronchitis — The Use of Human and Rat Models to Determine Mechanisms of Action of Oral Immunization with Haemophilus influenzae ....Pages 181-185 Oral Immunization for the Prevention of Dental Diseases....Pages 187-195 Front Matter....Pages 153-153 Oral Immunization Against Cholera....Pages 197-204 Oral Shigella Vaccines....Pages 205-211 The Enteric Immune Response to Shigella Antigens....Pages 213-223 Immune Response to Oral Salmonella Vaccines....Pages 225-231 Oral Immunization: A Summary....Pages 233-237