New Insights Into Cell And Membrane Transport Processes (new Horizons In Therapeutics)

Front Matter....Pages i-xxi Front Matter....Pages 1-1 Molecular Properties of Voltage-Sensitive Sodium Channels....Pages 3-20 Front Matter....Pages 21-21 Studies of a Biological Energy Transducer....Pages 23-38 The Erythrocyte Anion-Exchange Protein....Pages 39-59 The Lysosomal Proton Pump....Pages 61-74 Ion Pumps, Ion Pathways, Ion Sites....Pages 75-95 Front Matter....Pages 97-97 Shifts between Modes of Calcium Channel Gating as a Basis for Pharmacological Modulation of Calcium Influx in Cardiac, Neuronal, and Smooth-Muscle-Derived Cells....Pages 99-124 Chemical Pharmacology of Ca 2+ Channel Ligands....Pages 125-143 Information Flow in the Calcium Messenger System....Pages 145-174 Neutrophil Activation, Polyphosphoinositide Hydrolysis, and the Guanine Nucleotide Regulatory Proteins....Pages 175-198 Front Matter....Pages 199-199 Agonist-Dependent Phosphoinositide Metabolism....Pages 201-216 Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver....Pages 217-247 Comparison of the Na + Pump and the Ouabain-Resistant K + Transport System with Other Metal Ion Transport ATPases....Pages 249-259 Current Concepts of Tumor Promotion by Phorbol Esters and Related Compounds....Pages 261-274 Front Matter....Pages 275-275 Intracellular Protein Topogenesis....Pages 277-283 Analysis of Epithelial Cell Surface Polarity Development with Monoclonal Antibodies....Pages 285-304 Frequency and Time Domain Analysis of Epithelial Transport Regulation....Pages 305-326 The Epithelial Sodium Channel....Pages 327-344 Front Matter....Pages 345-345 Uptake and Intracellular Processing of Cell Surface Receptors....Pages 347-360 Sorting in the Prelysosomal Compartment (CURL)....Pages 361-375 Mechanisms of Molecular Sorting in Endosomes....Pages 377-402 Front Matter....Pages 345-345 Transport of Protein Toxins Across Cell Membranes....Pages 403-423 Back Matter....Pages 425-434