New Directions in Cancer Treatment (UICC International Union Against Cancer)

During the last few decades, there has been a tremendous improvement in the treatment of cancer. There is evidence that this trend is continuing, based on the achievements re­ sulting from the combined efforts of clinicians and basic re­ search workers. This book is an example of such interaction and collaboration. It was prepared by authors representing both areas of work. Most of the work reported in this book is not merely theoretical, but has been experimentally successfully tested and sometimes applied clinically. This work has, however, not yet been generalized and practiced on a wide scale. Some of the results reported here relate to new aspects and open new horizons for future progress. This book will be of great value for both clinicians and basic research workers. VICC Treatment and Rehabilitation Programme ISMAIL ELSEBAI Chairman Preface The three main approaches to the treatment of cancer are surgery, radiotherapy, and chemotherapy. Today, all malignant neoplasms are managed by one or more of these modalities, with varying success rates depending on the type of tumor, its degree of spread, and the knowl­ edge and skill with which the treatment plan has been designed and executed. In the United States of America and in Europe, approximate­ ly half of all cancer is presently curable, but this has been the case for approximately 20 years. Front Matter....Pages I-XVIII New Directions in Cancer Treatment: An Overview....Pages 1-27 Front Matter....Pages 29-29 New Approaches in Radiation Therapy....Pages 31-52 Radiotherapy Treatment Planning: Past, Present, and Future....Pages 53-84 Hyperthermia as Cancer Therapy: Current Status and Future Prospects....Pages 85-92 Photodynamic Therapy....Pages 93-116 Front Matter....Pages 117-117 Very High Dose Therapy in Lymphomas and Solid Tumors....Pages 119-142 Allogeneic Marrow Transplantation for Malignancy—Current Problems and Prospects for Improvement....Pages 143-165 Regional Therapies....Pages 166-190 Drug Resistance in Cancer....Pages 191-215 Multidrug Resistance in Tissue Culture and Human Tissues....Pages 216-226 Development of New Chemotherapeutic Agents....Pages 227-242 New Drug Trials....Pages 243-258 Drug Delivery to Brain Tumors....Pages 259-277 Front Matter....Pages 279-279 The Evaluation of Biological Response Modifiers for Cancer Therapy....Pages 281-296 Biologic Response Modifiers in Cancer Therapy....Pages 297-316 The Potential Value of Radiolabelled Monoclonal Antibodies in Cancer Therapy....Pages 317-324 Monoclonal Antibody Conjugates with Cytotoxic Agents for Cancer Therapy....Pages 325-342 Bone Marrow Purging....Pages 343-357 Future Prospects for the Treatment of Hormone-Responsive Tumors....Pages 358-378 Front Matter....Pages 379-379 Tumor Invasion and Metastases: Biochemical Mechanisms....Pages 381-398 Front Matter....Pages 379-379 Prospects for the Development of Antineoplastic Therapy Based on Molecular Pathology....Pages 399-427 Differentiation of Malignant Cells as a Strategy for Cancer Treatment....Pages 428-443 Front Matter....Pages 445-445 Malignant Brain Tumors....Pages 447-454 Head and Neck Cancer....Pages 455-458 Lung Cancer....Pages 459-462 Breast Cancer....Pages 463-467 Renal Cell Carcinoma....Pages 468-472 Carcinoma of the Pancreas....Pages 473-478 Hepatocellular Carcinoma....Pages 479-482 Esophageal Carcinoma....Pages 483-485 Gastric Cancer....Pages 486-490 Colon Cancer....Pages 491-495 Bladder Cancer....Pages 496-500 Prostate Cancer....Pages 501-504 Advanced Germ Cell Tumors....Pages 505-508 Ovarian Cancer....Pages 509-513 Trophoblastic Neoplasia....Pages 514-519 Malignant Adrenal Tumors....Pages 520-523 Neuroendocrine Tumors....Pages 524-527 Soft Tissue Sarcomas in Adults....Pages 528-533 Front Matter....Pages 445-445 Melanoma....Pages 534-540 Basal Cell Carcinoma....Pages 541-545 Acute Lymphoblastic Leukemia....Pages 546-551 Acute Nonlymphoblastic Leukemia....Pages 552-555 The Chronic Leukemias....Pages 556-560 Hodgkin’s Disease....Pages 561-565 Plasma Cell Myeloma....Pages 566-570 Follicular Non-Hodgkin’s Lymphomas....Pages 571-574 Diffuse Aggressive Lymphomas in Adults....Pages 575-579 Childhood Non-Hodgkin’s Lymphomas....Pages 580-584 Osteosarcoma....Pages 585-589 Ewing’s Sarcoma....Pages 590-594 Soft Tissue Sarcomas in Childhood....Pages 595-599 Wilms’ Tumor....Pages 600-604 Neuroblastoma....Pages 605-611 Retinoblastoma....Pages 612-615 Back Matter....Pages 617-634 This book brings together in one volume a large amount of information on the progress that is being made in developing novel and improved methods of cancer treatment. The first part of the book reviews areas such as: - physical treatment, including radiation therapy and hyperthermia; - chemotherapy, with particular interest in new drugs and methods of overcoming drug resistance; - biological approaches, including biological response modifiers, monoclonal antibodies and hormonal therapies; - and future approaches, such as the prevention of metastases, the induction of differentiation or even the utilization of the specific molecular lesions in cancer as a target for therapy. The second part deals with recent progress and future directions in particular types of cancer. The book is well referenced so as to serve as a base for more detailed exploration of any given topic. The dissemination of such new information aims to foster additional collaborative studies and possibly the development of new research protocols