New Developments in the Management of Gastric Cancer : Special Topic Issue: Digestive Diseases 2004, Vol. 22, No. 4

The overall prognosis for patients with gastric cancer remains poor as tumors are often diagnosed at an advanced stage, despite new developments and technical advances in endoscopic diagnosis and therapy. This publication brings together leading experts in the fields of basic research and clinical management of gastric cancer, to share their expertise with the clinical community. State-of-the-art reviews discuss the pathogenesis of and the most important risk factors for the development of gastric cancer, potential benefits of chemoprevention and Helicobacter pylori eradication. Moreover, new diagnostic modalities and surgical therapy, including the potential benefits of neoadjuvant and adjuvant therapies, are presented. As most patients require palliative therapy because of locally advanced or metastasized cancers, several reviews are dedicated to advances in the chemotherapy of advanced gastric cancers and peritoneal metastasis. Finally, future approaches towards a molecular diagnosis and therapy are described. Those involved in the management of gastric cancer patients will find the information presented in this publication of utmost help and will benefit greatly for their daily routine. Cover......Page 1 Contents......Page 4 Editorial......Page 5 Helicobacter pylori......Page 6 Host Genetic Factors......Page 7 Conclusions......Page 8 References......Page 9 Introduction......Page 10 Diet and Precancerous Lesions......Page 11 Genetic and Epigenetic Alterations in Intestinal Metaplasia......Page 12 Is Intestinal Metaplasia Reversible by H. pylori Eradication?......Page 13 References......Page 14 Introduction......Page 17 H. pylori and Inflammation......Page 18 Activation of Proliferation-Associated Signalling in H. pylori Infection......Page 19 Regression of Precancerous Lesions and Prevention of Gastric Cancer by H. pylori Eradication – Evidence from Clinical Trials......Page 20 Acknowledgement......Page 21 References......Page 22 Abstract......Page 24 In vitro Experimental Studies......Page 25 Human Studies......Page 26 Other Factors: H.pylori and Diet......Page 27 Conclusions......Page 28 References......Page 29 Introduction......Page 31 Endoscopic Clues to Detect Early Gastric Cancer......Page 33 New Modalities of Detecting Neoplastic Lesions......Page 35 References......Page 37 Introduction......Page 38 Endocytoscopy......Page 39 References......Page 41 Background......Page 42 Treatment Guidelines for EGC......Page 43 Endoscopic Mucosal Resection......Page 44 Modified Gastrectomy for EGC......Page 45 Superextended Para-Aortic Lymphadenectomy......Page 46 References......Page 47 Introduction......Page 49 Extended Lymph Node Dissection and/or Adjuvant Therapy?......Page 50 Neoadjuvant Multimodality Treatment: Chemotherapy or Chemoradiation?......Page 51 Conclusions......Page 52 References......Page 53 Surgery versus Endoscopy......Page 55 Indication......Page 56 Enteral Stenting......Page 57 Complications......Page 58 Nutritional Support in Gastric Cancer Patients......Page 59 Percutaneous Tube Feeding......Page 60 References......Page 62 5-FU and Combination Chemotherapy......Page 64 Platinum and Derivatives......Page 65 Irinotecan......Page 66 References......Page 68 Natural History......Page 70 Preoperative Chemotherapy......Page 71 Surgery......Page 72 Hyperthermic Chemotherapy......Page 73 Results......Page 74 IPHC as Prophylaxis......Page 75 References......Page 76 Cancer Gene Therapy......Page 78 Virotherapy......Page 80 Ways to Enhance Efficacy of Virotherapy......Page 81 References......Page 82 Introduction......Page 84 Molecular Diagnosis......Page 85 Molecular Therapy......Page 86 References......Page 88 Introduction......Page 90 Results......Page 91 Discussion......Page 92 References......Page 93 Introduction......Page 94 Esophagogastroduodenoscopy and Hp Status......Page 95 Discussion......Page 96 Acknowledgements......Page 98 References......Page 99 Introduction......Page 100 Manometric Findings......Page 101 Surgical Procedures and Follow-Up......Page 102 Discussion......Page 103 References......Page 105 Author Index......Page 106 N......Page 107 Z......Page 108 A collection of state-of-the-art reviews The overall prognosis for patients with gastric cancer remains poor as tumors are often diagnosed at an advanced stage, despite new developments and technical advances in endoscopic diagnosis and therapy. This publication brings together leading experts in the fields of basic research and clinical management of gastric cancer, to share their expertise with the clinical community. State-of-the-art reviews discuss the pathogenesis of and the most important risk factors for the development of gastric cancer, potential benefits of chemoprevention and Helico