New Developments in Biosciences: Their Implications for Laboratory Animal Science : Proceedings of the Third Symposium of the Federation of European Laboratory Animal Science Associations, Held in Amsterdam, The Netherlands, 1–5 June 1987

Front Matter....Pages I-XXI Opening Address: The Future of Laboratory Animal Use....Pages 1-6 The Acquired Immunedeficiency Syndrome in Man....Pages 7-10 Feline Acquired Immunodeficiency Syndromes....Pages 11-15 Immune Deficiency Syndrome in Rodents: The Nude Rat....Pages 17-28 Animal Welfare — Common Interest....Pages 29-30 Laboratory Animal .... Science — Service — Use....Pages 31-33 Laboratory Animal Science in Czechoslovakia....Pages 35-40 On the Ethology of Pain, its Experience and Expression....Pages 41-46 Pain in Neonates....Pages 47-51 Endorphins and Pain....Pages 53-57 Effects of Exogenous Pain Relieving Substances on Experimental Results....Pages 59-61 Veterinary Care at the Primate Center TNO....Pages 63-66 Developing Housing Facilities for Rhesus Monkeys: Prevention of Abnormal Behaviour....Pages 67-70 Microbiological Quality Assurance and Quality Assessment of Laboratory Animals....Pages 71-74 Centralisation — Decentralisation: Failure — Success....Pages 75-80 The Effect of Homogenization and Pasteurization on the Allergenicity of Bovine Milk Analysed by a Murine Anaphylactic Shock Model....Pages 81-86 Murine Passive Cutaneous Anaphylaxis Test (PCA) for the “All or None” Determination of Allergenicity of Bovine Whey Proteins and Peptides....Pages 87-92 Phenotypic and Patho-Morphological Characteristics in a Half-Sib-Family of Transgenic Mice Carrying Foreign MT-HGH Genes....Pages 93-98 The Housing and Handling of Marmosets and Tamarins Infected with Aids and Other Retroviruses....Pages 99-103 Long-Term Observation of Litter Intervals in Permanently Monogamous Mated Han:NMRI Mice....Pages 105-109 Genital Inflammation in Male Mice. A Microbiological Study....Pages 111-116 Microbial Assessment of a Single Fumigation by Formaldehyde of a Multi-Level Animal Facility....Pages 117-119 Mechanisms of Natural Selection Maintaining in Groups of Highly Standardized Mice and Rats, Influence on Infection Resistance....Pages 121-126 Provocation of Latent Infections....Pages 127-131 Introduction to Recombinant DNA Technology....Pages 133-141 DNA Hybridization as a Tool in Diagnosing Infectious Diseases. Comparison with Other Methods....Pages 143-146 Embryo Transfer and Manipulation....Pages 147-162 Strain Preservation of Rodent Embryos. Possibilities and Limitations....Pages 163-173 The Generation of Transgenic Animals and Their Use in Fundamental Research....Pages 175-183 On the Inheritance of Blood Characters in Mice....Pages 185-189 Investigating Genetic Variability between the MHS Hypertensive Strain of Rats and its Normotensive Control, MNS....Pages 191-196 Gene Mapping and Linkage Homology....Pages 197-201 A New Method to Produce Artificial Monozygotic Twins in Mice....Pages 203-208 Genetic Analysis of Multigenic Traits Using the Recombinant Congenic Strains....Pages 209-214 Acute Dermal Toxicity: Morphological Response of the Hairless Mice Skin Organ Culture....Pages 215-220 The Dutch Rabbit in Toxicity Testing Chemical — Induced Creatine Kinase Release; a Species- and Strain-Specific Response?....Pages 221-224 Intertrial — Interval in the “Water Escape Test” in Mice....Pages 225-230 Behaviour, Housing and Welfare of Non-Human Primates....Pages 231-237 Housing and Welfare of Laboratory Rodents....Pages 239-244 Housing Conditions and Experimental Results....Pages 245-254 Basis of the European Guidelines: Facts or Intuition?....Pages 255-265 Gnotobiotic Animals in Nutrition Research....Pages 267-276 Animal Models for Cholesterol Metabolism Studies....Pages 279-288 Animal Models in Hemostasis and Thrombosis....Pages 289-294 What’s your diagnosis? Mice with ulcerating Lesions on the Nose, Limbs and/or Tail ....Pages 295-298 Spontaneous Hyperplasia of the Endometrium in the rabbit....Pages 299-303 Monkey Graffity (environmental deficiency, boredom or artistic drive?)....Pages 305-309 Marking of African clawed toads ( Xenopus laevis ). Improvement of a skin autograft technique....Pages 311-316 Changes in Energy Intake, Body Weight Gains, Average Feed Efficiency and Some Plasma Hormone Levels in Dogs from Different Environments....Pages 317-324 Serum Concentrations of Vitamins A, D and E of Growing Beagles Fed Commercial Dog and Fox Diets....Pages 325-330 Integration of HGH Gene in Transgenic Mice and Transmission to Next Generation....Pages 331-336 Attempts to Produce Transgenic Rabbits Carrying MTI-HGH Recombinant Gene....Pages 337-341 Electrofusion of Early Mammalian Embryo Cells....Pages 343-347 Passive Infrared Movement Detector, a New Equipment to Monitor Motor Activity of Small Rodents in Normal Cages....Pages 349-352 Establishment of a SPF Population of Cricetulus griseus....Pages 353-358 Chronic Phlorizin Intoxication in Adipose Mutant Mice C57BL/KS db/db and in Normal Conrols....Pages 359-363 Plasma α-Amylase and Lipase Activities in Dogs with Variations in Food Composition and Availability....Pages 365-371 Locomotor Activity of a Behavior Mutant in NMRI Mice....Pages 373-374 The application of embryo transfer and cryopreservation to commerciel laboratory animal breeding....Pages 375-378 Serological Following of a Laboratory Rat Breeding Contaminated with Respiratory Viruses During 1981–1986....Pages 379-384 Eradication of Encephalitozoonosis in Rabbit Breeding Colonies by Carbon Immunoassay....Pages 385-387 Spontaneous Murine Hemosiderosis, A Model for Human Hemochromatosis?....Pages 389-392 In Vitro Adhesion of K88 Positive E. Coli to Intestinal Villi of Just-weaned Piglets....Pages 393-397 The Effects of Gentling on Open-field Behaviour of Rats....Pages 399-403 Blastomere Karyotyping: A Direct Method for Producing Mouse Trisomy 16 ↔ Diploid Aggregation Chimeras as an Animal Model of Human Down’s Syndrome....Pages 405-408 A Proposed Species Difference in the Renal Excretion of Perfluoro Octanoic Acid in the Beagle Dog and Rat....Pages 409-412 Measurement of Orthostatic Responses in Conscious Dogs....Pages 413-417 Oral 65Zn Loading Test in Rats Fed Iri-Ob Diet with Various Zn Concentrations....Pages 419-423 Mortality and Tumour Incidence of BDII/Han Rats....Pages 425-429 Assessment of Discomfort Induced by Orbital Puncture in Rats....Pages 431-436 Effect of Morphinomimetics in Different Pain Tests....Pages 437-442 Prevention of Early Deaths in Mice Contaminated with Gram Negative Enteric Bacteria and Fungus Following Irradiation....Pages 443-446 Detection of Mycoplasma neurolyticum in a colony of inbred mice: clinically silent infection....Pages 447-448 Effects of Handling and Transportation Stress on Rodents....Pages 449-457 This volume includes chapters originally presented at the 3rd FELASA Symposium, held in Amsterdam, June 1-5, 1987. Special topics were "Immune Deficiency Syndromes in Man and Animals", "DNA Technology and Laboratory Animal Science", "Interactions of Behaviour, Housing and Welfare", and "Laboratory Animals as Models in Biomedical Research". In addition, there was a great number of presentations concerning other aspects of laboratory animal science. We would like to thank the following persons for organizing the Symposium. Mrs. M.A.G. Kuipers, M. Sc., President FELASA Mrs. V. Baumans, D.V.M., Ph. D., Secretary FELASA P. de Vrey, D.V.M., Treasurer Mrs. I. Zaalmink, Organizing and Scientific Secretariat. The editors would also like to express their gratitude to all the participants and authors for their contribution to this succesful symposium. A.C. Beynen, Ph. D., Secretary Scientific Committee H.A. Solleveld, Ph. D., Chairman Scientific Committee FELASA Federation of European Laboratory Animal Science Associations Gesellschaft fUr Versuchstierkunde/Society for Laboratory Animal Science Laboratory Animal Science Association Nederlandse Vereniging voor Proefdierkunde Scandinavian Federation for Laboratory Animal Science Societe Fran9aise d'Experimentation Animale VII CONTENTS Contributors ... xiii OPENING ADDRESS: THE FUTURE OF LABORATORY ANIMAL USE R.J. Samsom ..