New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins (Advances in Biochemical Engineering/Biotechnology, 165)

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English. Front Matter ....Pages i-vi An Introduction to „Recent Trends in the Biotechnology Industry: Development and Manufacturing of Recombinant Antibodies and Proteins“ (Michael Pohlscheidt, Robert Kiss, Uwe Gottschalk)....Pages 1-8 New Mammalian Expression Systems (Jie Zhu, Diane Hatton)....Pages 9-50 Innovation in Cell Banking, Expansion, and Production Culture (Rashmi Kshirsagar, Thomas Ryll)....Pages 51-74 Risk Mitigation in Preventing Adventitious Agent Contamination of Mammalian Cell Cultures (Masaru Shiratori, Robert Kiss)....Pages 75-93 Manufacturing of Proteins and Antibodies: Chapter Downstream Processing Technologies (Richard Turner, Adrian Joseph, Nigel Titchener-Hooker, Jean Bender)....Pages 95-114 Downstream Processing Technologies/Capturing and Final Purification (Nripen Singh, Sibylle Herzer)....Pages 115-178 Fully Disposable Manufacturing Concepts for Clinical and Commercial Manufacturing and Ballroom Concepts (Berthold Boedeker, Adam Goldstein, Ekta Mahajan)....Pages 179-210 Trends in Process Analytical Technology: Present State in Bioprocessing (Marco Jenzsch, Christian Bell, Stefan Buziol, Felix Kepert, Harald Wegele, Christian Hakemeyer)....Pages 211-252 Next Generation Biopharmaceuticals: Product Development (Roman Mathaes, Hanns-Christian Mahler)....Pages 253-276 Continuous Manufacturing of Recombinant Therapeutic Proteins: Upstream and Downstream Technologies (Rohan Patil, Jason Walther)....Pages 277-322 Platforms for Manufacturing Allogeneic, Autologous and iPSC Cell Therapy Products: An Industry Perspective (Eytan Abraham, Behnam Baghbaderani Ahmadian, Kathryn Holderness, Yonatan Levinson, Erika McAfee)....Pages 323-350 Gene Therapy (Barb Thorne, Ryan Takeya, Francesca Vitelli, Xin Swanson)....Pages 351-399 High-Throughput Process Development for Biopharmaceuticals (Abhinav A. Shukla, Shahid Rameez, Leslie S. Wolfe, Nathan Oien)....Pages 401-441 A Different Perspective: How Much Innovation Is Really Needed for Monoclonal Antibody Production Using Mammalian Cell Technology? (Brian Kelley, Robert Kiss, Michael Laird)....Pages 443-462 Back Matter ....Pages 463-469