New Aspects of the Role of Adrenoceptors in the Cardiovascular System : Festschrift in Honour of the 65th Birthday of Prof. Dr. Hans-Joachim Schümann

This volume is the product of a symposium held on 14-16 February, 1985 in Hamburg in honour of the 65th birthday of Prof. Hans-Joachim Schumann. Schumann was born on 28 December, 1919 in Stralsund. He studied medicine in Cologne, Greifswald and Rostock. The chair of pharmacology in Rostock was held at that time by Peter Holtz. It was he who first introduced Schumann to pharmacology in 1944 and who was his Doktorvater (research supervisor). Mter the war, Schumann again worked with Holtz in Rostock and then in Frankfurt am Main. He received decisive stimuli during a research fellowship, in 1956, in Prof. J. H. Burn's department in Oxford, where he also worked with Prof. H. Blaschko. In 1964 he accepted his present position as ordentlicher (full) Professor and Head of the Institute of Pharmacology and Toxicology of the then newly founded Medical Faculty of Essen. He has remained in Essen despite being offered the chair of pharmacology in G6ttingen in 1968. It is interesting to observe how in the main lines of his scientific work, which now spans 40 years, Schumann has followed the steps involved in autonomic neurotransmission from transmitter release to transmitter-receptor interaction. He started with the identification of noradrenaline as an adrenal medullary hormone in its own right; continued with research on the vesicular storage of catecholamines, including the co-storage of catecholamines and ATP; then studied the presynaptic modulation of the release of noradrenaline; and in the last few years has concentrated on postsynaptic catecholamine receptors; in this field, his thorough investigations on myocardial a-adrenoceptors are particularly noteworthy. Schumann was President of the German Pharmacological Society from 1971 to 1974. He was elected an Mfiliate Member of the Royal Society of Medicine (London) and is also an Honorary Member of the Japanese Pharmacological Society. In Hamburg, his students, co-workers and colleagues from six countries joined Jochen and Annelies Schumann to celebrate a careful and stimulating scientist and a faithful and warm friend. The scientific papers read at the symposium and printed here reflect much of Schumann's own work as outlined above: from the central nervous control of blood pressure, via the mechanism and possible physiological function of the presynaptic modulation of sympathetic transmitter release, to myocardial and vascular adrenoceptors. May the volume express the contributors' esteem for VIII Table of Contents Front Matter....Pages I-X Front Matter....Pages 1-1 Involvement of Catecholaminergic Neurones of the Hypothalamus in Blood Pressure Regulation....Pages 3-13 On the Mechanism and Scope of Adrenoceptor-Mediated Control of Sympathetic Neuro-Effector Transmission: A Model Study....Pages 14-23 Presynaptic α -Adrenoceptor Control of Transmitter Release from Vascular Sympathetic Neurones in Vitro....Pages 24-32 Presynaptic β -Adrenoceptors in Human Blood Vessels and Their Possible Relationship to Adenylate Cyclase....Pages 33-42 In Vivo Operation of Prejunctional Adrenoceptors in the Peripheral Sympathetic Nervous System....Pages 43-56 Transmitter Coexistence in the Sympathetic Nervous System: Impact on Cardiovascular Regulation....Pages 57-65 Front Matter....Pages 67-67 Adrenoceptors in the Myocardium: Mechanical and Biochemical Events Resulting from Their Stimulation....Pages 69-77 Regulation of Myocardial Contractility Via Adrenoceptors: Differential Mechanisms of α - and β -Adrenoceptor-Mediated Actions....Pages 78-105 The Functional Role of the Coexistence of β 1 - and β 2 -Adrenoceptors in the Human Heart....Pages 106-120 Effect of Thyroid Hormones on Myocardial Adrenoceptors and Adrenoceptor-Mediated Cardiovascular Responses in the Rat....Pages 121-128 Postsynaptic α -Adrenoceptors in Blood Vessels: Discrepancies between Results Obtained in Vivo and in Vitro....Pages 129-138 Adrenaline Reversal and Postjunctional α -Adrenoceptors....Pages 139-144 Back Matter....Pages 145-145 This volume is the product of a symposium held on 14-16 February, 1985 in Ham burg in honour of the 65th birthday of Prof. Hans-Joachim Schumann. Schumann was born on 28 December, 1919 in Stralsund. He studied medicine in Cologne, Greifswald and Rostock. The chair of pharmacology in Rostock was held at that time by Peter Holtz. It was he who first introduced Schumann to pharma cology in 1944 and who was his Doktorvater (research supervisor). Mter the war, Schumann again worked with Holtz in Rostock and then in Frankfurt am Main. He received decisive stimuli during a research fellowship, in 1956, in Prof. J.H. Burn's department in Oxford, where he also worked with Prof. H. Blaschko. In 1964 he ac cepted his present position as ordentlicher (full) Professor and Head of the Institute of Pharmacology and Toxicology of the then newly founded Medical Faculty of Es sen. He has remained in Essen despite being offered the chair of pharmacology in G6ttingen in 1968. It is interesting to observe how in the main lines of his scientific work, which now spans 40 years, Schumann has followed the steps involved in autonomic neuro transmission from transmitter release to transmitter-receptor interaction