New Aspects of Human Polymorphonuclear Leukocytes (Advances in Experimental Medicine and Biology, 297)

Proceedings of a workshop held in Freiburg, Germany, October 26--28, 1989 Front Matter....Pages i-viii Electrophysiological Properties of Human Neutrophils....Pages 1-11 Mechanisms of Neutrophil and Macrophage Motility....Pages 13-22 Diversity in Motile Responses of Human Neutrophil Granulocytes: Functional Meaning and Cytoskeletal Basis....Pages 23-37 Leukodiapedesis, Compartmentalisation and Secretion of PMN Leukocyte Proteinases, and Activation of PMN Leukocyte Procollagenase....Pages 39-53 Role of Platelet Activating Factor in the Adhesion Process of Polymorphonuclear Neutrophils to Endothelial Cells....Pages 55-64 Mechanisms of Lipopolysaccharide Priming for Enhanced Respiratory Burst Activity in Human Neutrophils....Pages 65-73 The Effect of Inflammatory Mediators on Neutrophil Function....Pages 75-92 Clinical Evaluation of Hematopoietic Growth Factors....Pages 93-102 Neutrophil Function in Polycythemia Vera....Pages 103-109 Human Tumor Cell Urokinase-Type Plasminogen Activator (uPA): Degradation of the Proenzyme form (pro-uPA) by Granulocyte Elastase Prevents Subsequent Activation by Plasmin....Pages 111-128 Anca: A Class of Vasculitis-Associated Autoantibodies Against Myeloid Granule Proteins: Clinical and Laboratory Aspects and Possible Pathogenetic Implications....Pages 129-139 Anti-Cytoplasmic Antibodies in Wegener’s Granulomatosis are Directed Against Proteinase 3....Pages 141-150 Neutrophil Carbohydrate Metabolism in Patients with Essential Hypertension and Uremia....Pages 151-160 Effect of Sulfated Glycosaminoglycans on the Inhibition of Neutrophil Elastase by α 1 -Proteinase Inhibitor....Pages 161-165 C5a Receptors on Neutrophils and Monocytes from Chronic Dialysis Patients....Pages 167-181 Respective Influence of Uremia and Hemodialysis on Whole Blood Phagocyte Oxidative Metabolism, and Circulating Interleukin-1 and Tumor Necrosis Factor....Pages 183-192 Phagocyte Function in Uremia....Pages 193-205 New Aspects on Oxidative Metabolism of Neutrophils During Hemodialysis on Different Dialyzer Membranes....Pages 207-213 Blood Flow Dependent Granulocyte Activation in Membranes with and Without Complement Activation....Pages 215-224 Back Matter....Pages 225-228 We are pleased to present our readers the proceedings of the International symposium on "New Aspects of Human Polymorpho nuclear Leukocytes" which was held in Freiburg im Breisgau, FRG, from October 26-28th, 1989. The meeting provided an unique framework for close interaction between scientists from various disciplines, including bioche mistry, biology, physiology, pathology, clinical chemistry, hematology, gynecology, surgery, intensive care medicine, nephrology, rheumatology, and infectious diseases. We would like to express our gratitude and appreciation for all those who have stimulated, encouraged, and supported us to hold the symposium in Freiburg. This endeavor could not have been possible without the generous financial support of Asid Bonz (Böblingen), Bayer AG (Leverkusen), Bayropharm GmbH (Köln), Baxter (München), Ciba-Geigy (Wehr/Baden), Cilag GmbH (Sulzbach), Fresenius AG (Oberursel), Gambro (Martinsried), Gry-Pharma GmbH (Kirchzarten), Hoechst AG (Frankfurt), Hospal (Nürnberg), Knoll AG (Ludwigshafen), Lederle-Cyanamid (Wolfratshausen), E. Merck (Darmstadt), MSD Sharp and Dohme GmbH (München), Pfizer GmbH (Karlsruhe), and Kabi/Pfrimmer (Erlangen). We are indebted to Mrs. I. Szkibik for her invaluable ass i stance both with the organization of the meeting and the pre paration of the manuscripts Proceedings of an international symposium in Freiburg, Germany, October 1989. Among the 19 papers are discussions of the mechanisms of neutrophii and macrophage motility, the clinical evaluation of hematopoietic growth factors, and the effect of inflammatory mediators on neutrophil function