New Aspects in the Diagnosis and Treatment of Hodgkin’s Disease: First International Symposium on Hodgkin's Lymphoma in Cologne, October 2-3, 1987 (Recent Results in Cancer Research, 117)

In the field of Hodgkin's lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa­ tients even in the advanced stages. Therefore, it seems to be justi­ fied to compile these new data in a special volume of Recent Re­ sults in Cancer Research. This volume summarizes the contribu­ tions presented at the First International Symposium on Hodgkin's Disease that took place in Cologne (FRG) on October 2-3, 1988. There is little doubt that the Hodgkin and Reed-Sternberg (H and RS) cells and their variants represent the malignant population in Hodgkin's lymphoma; however, there is still a fierce debate as to the possible cell of origin of Hand RS cells. Many of the problems confounding earlier research into this question were related to the difficulty or virtual impossibility, of obtaining purified populations of Hand RS cells. Most of the recent progress stems from the establishment of permanent cell lines of Hand RS cells in culture. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Pathology of Hodgkin’s Disease: Anything New?....Pages 3-13 Immunology of Hodgkin and Reed-Sternberg Cells....Pages 14-26 DNA Gene Rearrangement Studies in Hodgkin’s Disease and Related Lymphomas: A Contribution to Their Cellular Origin....Pages 27-34 Genetics of Hodgkin’s Lymphoma....Pages 35-49 Front Matter....Pages 51-51 Biology of Hodgkin Cell Lines....Pages 53-61 Phenotypic and Genotypic Analysis of Two Cell Lines Derived from Hodgkin’s Disease Tissue Biopsies....Pages 62-66 The Typical Reed-Sternberg Phenotype and I g Gene Rearrangement of Hodgkin’s Disease Derived Cell Line ZO Indicating a B-Cell Origin....Pages 67-74 Characterization of Hodgkin’s Disease Derived Cell Line HDLM-2....Pages 75-82 A New Hypothesis on the Cellular Origin of Reed-Sternberg and Hodgkin Cells Based on the Immunological and Molecular Genetic Analysis of the KM-H2 Line....Pages 83-90 A Marker and Putative Pathoantigen of Hodgkin’s Cells....Pages 91-98 Front Matter....Pages 99-99 Radiolabeled Monoclonal Antibodies Against Reed-Sternberg Cells for in Vivo Imaging of Hodgkin’s Disease by Immunoscintigraphy....Pages 101-111 Diagnostic Strategies and Staging Procedures for Hodgkin’s Lymphoma: Bone Marrow Scintigraphy and Magnetic Resonance Imaging....Pages 112-119 Front Matter....Pages 121-121 Radiotherapy Trials in Hodgkin’s Disease....Pages 123-131 Current Status of Chemotherapy for Hodgkin’s Disease....Pages 132-141 Risk Factor Adapted Treatment of Hodgkin’s Lymphoma: Strategies and Perspectives....Pages 142-162 Reduced Combined Radiotherapy and Chemotherapy for Hodgkin’s Disease — Risk-Adapted Treatment Approach....Pages 163-168 Hodgkin’s Disease: The Milan Cancer Institute Experience with MOPP and ABVD....Pages 169-174 EORTC Lymphoma Cooperative Group Studies in Clinical Stage I-II Hodgkin’s Disease 1963–1987....Pages 175-181 Current Stanford Clinical Trials for Hodgkin’s Disease....Pages 182-190 Results and Prognostic Factors Following Optimal Treatment of Advanced Hodgkin’s Disease....Pages 191-196 Front Matter....Pages 121-121 Two Cycles of MOPP and Definitive Radiotherapy for Stage IIIA and IIIB Hodgkin’s Disease....Pages 197-204 Risk Factor Adapted Treatment of Hodgkin’s Lymphoma in Childhood: Strategies and Results of Three Consecutive Multicenter Studies in the Federal Republic of Germany....Pages 205-213 Hodgkin’s Disease in Children: Adaptation of Treatment to Risk Factors....Pages 214-221 Front Matter....Pages 223-223 Conventional Salvage Therapy for Hodgkin’s Lymphoma....Pages 225-232 High-Dose Combination Chemotherapy with Cyclophosphamide, Carmustine, Etoposide, and Autologous Bone Marrow Transplantation in 60 Patients with Relapsed Hodgkin’s Disease: The M. D. Anderson Experience....Pages 233-238 Treatment of Resistant Hodgkin’s Lymphoma with Bone Marrow Transplantation in Italy....Pages 239-241 Preliminary Results of Autologous Bone Marrow Transplantation in the Management of Resistant Hodgkin’s Disease: Experience of the Bloomsbury Transplant Group at University College, London....Pages 242-245 Bone Marrow Transplantation in the Treatment of Hodgkin’s Lymphoma: Problems, Remaining Challenges, and Future Prospects....Pages 246-253 Front Matter....Pages 255-255 Quality of Life During and After Treatment of Hodgkin’s Disease....Pages 257-269 Risk of Secondary Acute Leukemia and Preleukemia After Hodgkin’s Disease: The Institut Gustave-Roussy Experience....Pages 270-283 This work contains recent results of basic and clinical studies in Hodgkin's disease up to early 1988. It deals with tumor immunological, genetical and molecular biological findings obtained from Hodgkin's derived cell lines and biopsies of lymphomas in Hodgkin's disease. New aspects concerning the histopathology of Hodgkin's disease are also described. In the clinical section recent developments in diagnosis such as immunoscintigraphy with monoclonal antibodies and bone marrow scintigraphy are dealt with, as are new therapeutic approaches that take into account the relevance of risk factor analysis for therapeutic strategies. Finally, new therapeutic avenues such as bone marrow transplantation are covered in detail. The best known researchers in the field present their latest data in this volume, thus assuring that all relevant aspects of Hodgkin's disease are covered