New Approaches to Drug Discovery (Handbook of Experimental Pharmacology, 232)

In depth insights into drug discovery and early drug development Latest technologies of target discovery and lead generation New approaches to transfer drug candidates to clinical development This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase. Topics Pharmacology / Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Front Matter....Pages i-viii Trends in Modern Drug Discovery....Pages 3-22 Functional Genomics in Pharmaceutical Drug Discovery....Pages 25-41 Emerging Target Families: Intractable Targets....Pages 43-58 In Vivo Target Validation Using Biological Molecules in Drug Development....Pages 59-70 High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization....Pages 73-89 Sources for Leads: Natural Products and Libraries....Pages 91-123 New Compound Classes: Protein–Protein Interactions....Pages 125-138 Using Cheminformatics in Drug Discovery....Pages 139-168 Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays....Pages 171-190 Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators....Pages 191-202 Predictive In Vivo Models for Oncology....Pages 203-221 Translational In Vivo Models for Cardiovascular Diseases....Pages 223-234 Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety....Pages 235-260 Nonclinical Safety and Toxicology....Pages 261-283 Impact of Biomarkers on Personalized Medicine....Pages 285-311 Modeling and Simulation of In Vivo Drug Effects....Pages 313-329 Back Matter....Pages 331-341 "This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase." -- Font no determinada