New Applications of NMR in Drug Discovery and Development (New Developments in NMR (Volume 2))

Content: Introduction; Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High; Resolution NMR in Drug Discovery and Development; Solid-state NMR in Drug Discovery and Development; Part II. The Whole Organism in Vivo: Increased Sensitivity Using Cryogenic; Radiofrequency Coils: Application to In Vivo Phenotyping of Mice; Recent Developments of Contrast Agents, CEST and Low Fields; Pharmacological fMRI in Drug Discovery and Development; Part III. Translational drug discovery: From Biological Models to the Clinics; Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges This Book Presents A Review Of Recent Developments In Nmr Applications In Pharmaceutical Research. Consideration Is Given To Consolidated And Emerging Techniques And Methods In Nmr, Many Of Which Are Not Widely Applied But Are Likely To Provide New Opportunities For Drug Design. The First Part Of The Book Is Dedicated To The Description Of Nmr As A Tool For The Analysis Of Chemicals And Interaction With Targets. The First Part Of The Book Is Dedicated To The Description Of Nmr As A Tool For The Analysis Of Chemicals And Interaction With Targets. Particular Emphasis Is Put On Applications With Unexploited Potential For Drug Discovery And Development. The Next Seven Chapters Describe Nmr Approaches To Investigate In Vivo Models Of Interest In Drug Discovery And Development, With The Attention Focused On Anatomy, Function, Metabolism And Molecular-cellular Aspects. Finally, Consideration Is Given To The Application Of In Vivo Nmr To The Identification And Characterization Of Biomarkers With The Aim Of Monitoring The Outcome Of Therapeutic Intervention In Selected Human Diseases, Including The Study Of Drug Metabolism And Toxicity. Aimed At Nmr Spectroscopists And Pharmaceutical Scientists, This Title Will Be Invaluable At Putting Nmr Within Context In Its Role In Drug Discovery And Development. This Resource Will Be Essential Reading For Those Both New And Already Active In These Areas. Edited By Leoncio Garrido, Nicolau Beckmann. Mode Of Access: World Wide Web. This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods, many of which are not yet widely applied but are likely to provide new opportunities for drug design.