Neurotransmitter Receptors: Mechanisms of Action and Regulation (Advances in Experimental Medicine and Biology, 175)

This meeting was held commemorating Dr. Kito's 10th Anniversary as Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito was born in 1927 in Nagoya, graduated from Tokyo University School of Medicine and received his M. D. in 1951. He spent his first academic years as a research associate (1952 - 1968) at the Third Department of Internal Medi­ cine, Tokyo University School of Medicine. During this period he studied for one year (1952 - 1953) at Illinois University School of Medicine, and acquired his Ph. D. in 1959. In 1968 he became Instructor and in 1971 he was appointed as Assistant Professor of Tokyo Women's Medical College. In 1973, he became Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito is a clinician but he is always enthusiastic about basic medicine. His major research field concerns neurotrans­ mitters and their receptors in the central nervous system. He prefers a combination of neurotransmitter immunohistochemistry and receptor autoradiography as research techniques. He is also engaged in biochemical studies on amyloid proteins. When the Eighth Inter­ national Congress of Pharmacology was held in Tokyo in 1981, Dr. Segawa, Dr. Yamamura, and Dr. Kuriyama organized a Satellite Symposium on Neurotransmitter Receptors in Hiroshima. Dr. Kito attended this meeting and was deeply impressed by the active presentations and discussions. In order to make some contribution to the progress of neuro­ sciences, Dr. Front Matter....Pages i-xi Selective Blockage by Islet-Activating Protein, Pertussis Toxin, of Negative Signal Transduction from Receptors to Adenylate Cyclase....Pages 1-16 A Central Role for Magnesium in the Regulation of Inhibitory Adenosine Receptors....Pages 17-30 Role of Hormone-Sensitive GTPases in Adenylate Cylase Regulation....Pages 31-45 Reconstitution of the Regulatory Functions of β-Adrenergic Receptors....Pages 47-62 Regulation of the Catalytic Unit of Adenylate Cyclase System in Rat Brain....Pages 63-74 Molecular Regulatory Mechanism of D 2 Dopamine Receptor in the Bovine Striatum....Pages 75-84 Genetic and Functional Studies of Guanine Nucleotide-Binding Regulatory Proteins....Pages 85-98 Differential Regulation of Putative M 1 /M 2 Muscarinic Receptors: Implications for Different Receptor-Effector Coupling Mechanisms....Pages 99-114 Factors Regulating Ligand Binding to 5-Hydroxytryptamine Receptors in Rat Brain....Pages 115-125 Evidence for Alpha 2 Adrenergic Receptors in Bovine Cerebral Arteries....Pages 127-132 Modulation of Alpha 2 -Adrenergic Receptors of Rat Vas Deferens by Adenosine Receptors....Pages 133-143 Neuromodulatory Roles of Adenosine Receptors Coupling to the Calcium Channel and Adenylate Cyclase....Pages 145-158 Interaction of Enkephalin with Opioid Receptors of Brain Membranes: Regulation by Essential Transition Metals, Guanine Nucleotides and Temperature....Pages 159-171 Ca 2+ -Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca 2+ and Mg-GTP in the Activation....Pages 173-186 Modulation of Neuroreceptor Functions by Lipomodulin, a Phospholipase Inhibitory Protein....Pages 187-192 Ontogenetic Development of the Specific [ 3 H]Nitrendipine Binding Sites in the Rat Whole Brain....Pages 193-204 Biochemical Properties of the GABA/Barbiturate/Benzodiazepine Receptor-Chloride Ion Channel Complex....Pages 205-219 Purification of γ-Aminobutyric Acid (GABA) and Benzodiazepine Receptors from Rat Brain Using Benzodiazepine-Affinity Column Chromatography....Pages 221-233 Structure and Properties of the Brain GABA/Benzodiazepine Receptor Complex....Pages 235-254 Use of Autoradiographic Techniques for the Localization of Neurotransmitter Receptors in Brain and Periphery: Recent Applications....Pages 255-270 The Structure and Evolution of Neurotransmitter Receptors (α- and β-Adrenergic, Dopaminergic and Muscarinic Cholinergic)....Pages 271-288 Back Matter....Pages 289-297