Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology (Current Topics in Behavioral Neurosciences Book 29)

This Book Is Authored By Leading Experts Who Made Major Discoveries In Neuroteratology Research Focused On Modeling Human Neural Developmental Disorders. Individual Chapters Address Adhd (attention-deficit Hyperactivity Disorder), Lesch-nyhan Disease, Psychoses And Schizophrenia, Autism, And Models Of Parkinson's Disease And Tardive Dyskinesia. The Effects Of Perinatal Stress And Agonist Insults On Life-long Outcomes Are Addressed, As Well As The Overall Effects Of Perinatal Neurotoxins On Development Of Specific Neural Phenotypic Systems. The Book Provides A Unique Compendium On How Perinatal Insults Of Various Types Can Produce Effects In Brain That Persist Throughout The Life Span. Researchers Can Derive Insight Into Experimental Approaches In This Research Field; Clinicians Can Develop Insights Into The Influences Of The Many Noxious And Seemingly Innocuous Substances That Might Influence Brain Development In Children. From The Contents: Preface -- Adhd Modeling By Perinatal Insult In Animals -- Perinatal Insults To Model Human Neuro-psychiatric Disorders -- Selective Life-long Destructive Of Brain Monoaminergic Nerves -- Ngf In Perinatal Development -- Life-long Susceptibility Consequent To Perinatal Substances Of Abuse -- Schizotypic Effects Of Perinatal Insults. Richard M. Kostrzewa, Trevor Archer, Editors. Front Matter....Pages i-viii Neuroteratology and Animal Modeling of Brain Disorders....Pages 1-40 Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa....Pages 43-50 Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment....Pages 51-71 Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection....Pages 73-86 Perinatal Domoic Acid as a Neuroteratogen....Pages 87-110 Perinatal 192 IgG-Saporin as Neuroteratogen....Pages 111-123 NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems....Pages 125-152 Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders....Pages 155-181 Neurobehavioral Effects from Developmental Methamphetamine Exposure....Pages 183-230 Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases—an Overview of Experimental Studies....Pages 231-264 The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease....Pages 265-277 Perinatal 6-Hydroxydopamine Modeling of ADHD....Pages 279-293 Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems....Pages 295-311 Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson’s Disease....Pages 313-332 Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings....Pages 333-351 Lifelong Rodent Model of Tardive Dyskinesia—Persistence After Antipsychotic Drug Withdrawal....Pages 353-362 Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism....Pages 363-386 Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor....Pages 387-402 Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review....Pages 403-428 Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling....Pages 429-446