Neurotoxicity of Metals (Advances in Neurobiology, 18)

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease. Front Matter ....Pages i-vi Front Matter ....Pages 1-1 Developmental Neurotoxicity of Lead (Samuel Caito, Michael Aschner)....Pages 3-12 Manganese and Developmental Neurotoxicity (Roberto Lucchini, Donatella Placidi, Giuseppa Cagna, Chiara Fedrighi, Manuela Oppini, Marco Peli et al.)....Pages 13-34 Inherited Disorders of Manganese Metabolism (Charles E. Zogzas, Somshuvra Mukhopadhyay)....Pages 35-49 Front Matter ....Pages 51-51 Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity (C. S. Oliveira, B. C. Piccoli, M. Aschner, J. B. T. Rocha)....Pages 53-83 Metals and Paraoxonases (Lucio G. Costa, Toby B. Cole, Jacqueline M. Garrick, Judit Marsillach, Clement E. Furlong)....Pages 85-111 Manganese and the Insulin-IGF Signaling Network in Huntington’s Disease and Other Neurodegenerative Disorders (Miles R. Bryan, Aaron B. Bowman)....Pages 113-142 Occupational Metal Exposure and Parkinsonism (W. Michael Caudle)....Pages 143-158 Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity (Ronald B. Tjalkens, Katriana A. Popichak, Kelly A. Kirkley)....Pages 159-181 Aluminum and Alzheimer’s Disease (Maria Teresa Colomina, Fiona Peris-Sampedro)....Pages 183-197 Copper and Alzheimer’s Disease (Zoe K. Mathys, Anthony R. White)....Pages 199-216 Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings? (Céline Dinocourt)....Pages 217-225 Neurotoxicity of Metal Mixtures (V. M. Andrade, M. Aschner, A. P. Marreilha dos Santos)....Pages 227-265 Methylmercury-Induced Neurotoxicity: Focus on Pro-oxidative Events and Related Consequences (Marcelo Farina, Michael Aschner)....Pages 267-286 Neurotoxicity of Vanadium (Hilary Afeseh Ngwa, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy)....Pages 287-301 Neurotoxicity of Zinc (Deborah R. Morris, Cathy W. Levenson)....Pages 303-312 Neurotoxicity of Copper (Felix Bulcke, Ralf Dringen, Ivo Florin Scheiber)....Pages 313-343 Thallium Toxicity: General Issues, Neurological Symptoms, and Neurotoxic Mechanisms (Laura Osorio-Rico, Abel Santamaria, Sonia Galván-Arzate)....Pages 345-353 Neurodegeneration Induced by Metals in Caenorhabditis elegans (Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila)....Pages 355-383 In this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease