Neurosteriods: A New Regulatory Function in the Nervous System (Contemporary Endocrinology)

Etienne-emile Baulieu, The Discoverer Of Neurosteroids, And A Panel Of Distinguished Scientists And Clinical Researchers Exhaustively And Critically Review All Facets Of Neurosteroids Involved In Behavior, Stress, Memory, Depression, Anxiety, Aging Of The Brain, And Neurodegenerative Diseases. These Contributors Illuminate The Role Of Neurosteroids In Brain Development And Plasticity And Detail Their Neuromodulatory Influence On Gabaa, Ionotropic Glutamate Receptors, Acetylcholine Receptors, Sigma Receptors, And Calcium Channels. Clearly Pointing The Way Toward Novel Pharmaceutical Agents That May Be Of Significant Therapeutic Value, Particularly With Regard To Aging Mental Functions, Neurosteroids: A New Regulatory Function In The Nervous System Offers Neurobiologists, Psychiatrists, Neurosurgeons, Pharmacologists, And Geriatricians The First Comprehensive, State-of-the-art Review Of These Important Bioactive Molecules.--publisher Description (loc). List Of Main Steroids And Enzymes Involved In Steroid Metabolism -- 1. Neurosteroids: From Definition And Biochemistry To Physiopathologic Function / Paul Robel, Michael Schumacher And Etienne-emile Baulieu -- 2. Molecular Biology And Developmental Regulation Of The Enzymes Involved In The Biosynthesis And Metabolism Of Neurosteroids / Synthia H. Mellon And Nathalie A. Compagnone -- 3. Cytochrome P450 In The Central Nervous System / Margaret Warner And Jan-ake Gustafsson -- 4. Steroidogenic Factor 1 Plays Key Roles In Adrenal And Gonadal Development And In Endocrine Function / Kathleen M. Caron, Yayoi Ikeda And Xunrong Luo / [and Others]. Edited By Etienne-emile Baulieu, Paul Robel, Michael Schumacher. Includes Bibliographical References And Index. Unveils new physiological properties of neurosteroids, the related steroids that can form and metabolize the brain, as well as throughout the entire nervous system. The discussions here may be the key to discovering new approaches to the repair of the nervous system after trauma and degenerative diseases. In the CONTEMPORARY ENDOCRINOLOGY series. The relationships between steroid hormones and brain function have mostly been envisioned within the framework of endocrine mechanisms as responses elicited by secretory products of steroidogenic endocrine glands, borne by the blood stream, and exerting actions on the brain.