Neuroscience Databases : A Practical Guide

Neuroscience Databases: A Practical Guide is the first book providing a comprehensive overview of these increasingly important databases. This volume makes the results of the Human Genome Project and other recent large-scale initiatives in the neurosciences available to a wider community. It extends the scope of bioinformatics from the molecular to the cellular, microcircuitry and systems levels, dealing for the first time with complex neuroscientific issues and leading the way to a new culture of data sharing and data mining necessary to successfully tackle neuroscience questions. Aimed at the novice user who wants to access the data, it provides clear and concise instructions on how to download the available data sets and how to use the software with a minimum of technical detail with most chapters written by the database creators themselves. Key databases and topics include: -Neuroinformatics for C. Elegans; -Gene Expression Patterns; -Functional Analyses of Olfactory Receptors -Protein-Protein Interactions; -Web-Based Neuronal Archives; -Neuronal and Network Modeling; -Storage and Retrieval of Experimental Data for Biophysically Realistic Modeling; -Analysis of Spike Trains; -Neural Connectivity Patterns; -Software Tools for Neuroimaging; -Data Management, Inspection and Sharing. Front Matter....Pages i-xviii Neuroinformatics for C. elegans : Relating Mind and Body in Wormbase....Pages 1-17 A Gene Expression Map of the Mouse Brain....Pages 19-35 Databases for the Functional Analyses of Olfactory Receptors....Pages 37-50 Construction of a Protein-Protein Interaction Database (PPID) for Synaptic Biology....Pages 51-62 Modeling The Dynamics of Second Messenger Pathways....Pages 63-79 Web-Based Neuronal Archives....Pages 81-97 ModelDB: A Resource for Neuronal and Network Modeling....Pages 99-109 CoCoDat: Collation of Cortical Data on Neurons and Microcircuitry....Pages 111-122 Computer Models and Analysis Tools for Neural Microcircuits....Pages 123-138 A Practical Guide to Information Analysis of Spike Trains....Pages 139-154 An Introduction to CoCoMac-Online....Pages 155-169 Graph Theory Methods for the Analysis of Neural Connectivity Patterns....Pages 171-185 The PUPS-MOSIX Environment: A Homeostatic Environment for Neuro- and Bio-informatic Applications....Pages 187-202 The NeuroHomology Database: An Online KMS for Handling and Evaluation of the Neurobiological Information....Pages 203-219 The fMRI Data Center: Software Tools for Neuroimaging Data Management, Inspection, and Sharing....Pages 221-235 Statistical Parametric Mapping....Pages 237-250 The Brain Positioning Software....Pages 251-258 BrainInfo....Pages 259-273 Federation of Brain Data through Knowledge-guided Mediation....Pages 275-291 Facilitating Data and Software Sharing in the Neurosciences — a Neuroinformatics Portal....Pages 293-306 Back Matter....Pages 307-310