Neuroreceptor Mechanisms in Brain (Advances in Experimental Medicine and Biology, 287)

The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym­ posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers contained in this volume constitute a state­ of-the-art survey of the most advanced aspects of neurotransmitter recep­ tor mechanisms in the brain. lowe thanks for the great success of the symposium to Prof. Richard Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya Tohyama of Osaka University. I express my sincere gratitude to many friends for making this publication possible. I especially thank Dr. Rie Miyoshi, whose devoted efforts as secretary-general were vital to the success of the symposium. Dr. Miyoshi is currently an instructor in the Department of Pharmacology at Tokyo Women's Medical College. I would also like to acknowledge the excellent secretarial work of Misses Ritsuko Sato and Yuko Wakita. Front Matter....Pages i-xii Effect of Neuropeptides on Classic Types of Neurotransmission in the Rat Central Nervous System....Pages 1-11 Solubilization and Characterization of Substance P Receptors in the Central Nervous System....Pages 13-25 Evidence for Cardiovascular Roles of Tachykinin Peptides in the Brain of the Rat....Pages 27-37 Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide, on the Neuromuscular Junction....Pages 39-50 Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes....Pages 51-59 Transmitter-Activated Ion Channels as the Target of Chemical Agents....Pages 61-73 Chemical Kinetic Investigations of the Channel-Opening Process of Neurotransmitter Receptors....Pages 75-82 Primary Structure and Functional Expression of the Inositol 1,4,5-Trisphosphate Receptor, P400....Pages 83-95 Inositol 1,4,5-Trisphosphate Activates Ca 2+ Channels in the Plasma Membranes of Rat Brain Nerve Terminals....Pages 97-110 Formation of Inositol Polyphosphates in Cultured Adrenal Chromaffin Cells....Pages 111-123 Effects of Oxygen Depletion on Phosphoinositide Breakdown in Rat Brain Slices....Pages 125-139 Expression of G-Protein α-Subunit cDNA....Pages 141-149 Serotonin Receptor Subtypes in Brain: Ligand Binding Properties and Coupling with G Proteins....Pages 151-164 A Cerebral Endogenous Factor Regulates the Activity of the Serotonergic Receptors Modulating the Neuronal Release of Acetylcholine....Pages 165-176 Serotonin Receptor Heterogeneity and the Role of Potassium Channels in Neuronal Excitability....Pages 177-191 Modulatory Actions of Norepinephrine on Neural Circuits....Pages 193-208 Genetic Analysis of the β -Adrenergic Receptor....Pages 209-220 Reversal of Nigrostriatal-Lesion-Induced Receptor Alterations by Grafting of Fetal Mesencephalic Dopaminergic Neurons....Pages 221-235 Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors....Pages 237-240 Depression of NMDA-Evoked Acetylcholine Release by Endogenous Adenosine in Striatum Slices....Pages 241-248 Imaging of Dopamine D1 and D2 Receptors by a High Resolution Positron Emission Tomography....Pages 249-253 The Nicotinic Acetylcholine Receptor Gene Family: Structure of Nicotinic Receptors from Muscle and Neurons and Neuronal α-Bungarotoxin-Binding Proteins....Pages 255-278 Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases....Pages 279-294 Affinity Purification of Nicotinic Acetylcholine Receptor from Rat Brain....Pages 295-299 Differential Coupling of Subtypes of the Muscarinic Receptor to Signaling Mechanisms in Brain and Peripheral Tissues....Pages 301-312 The Molecular Properties of the M 1 Muscarinic Receptor and its Regulation of Cytosolic Calcium in a Eukaryotic Gene Expression System....Pages 313-330 Molecular Mechanism Underlying the Occurrence of Supersensitivity at Muscarinic Receptors: Analysis Using Cerebral Cortical Neurons in Primary Culture....Pages 331-342 Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia....Pages 343-347 Intramembrane Particles in the Postsynaptic Membranes of the S-, F-, and C-Type Synapses by Freeze-Fracturing, and Deep-Etching Studies on the Xenopus Spinal Cord....Pages 349-354 GABA A -Benzodiazepine Receptors: Demonstration of Pharmacological Subtypes in the Brain....Pages 355-364 Structural, Developmental and Functional Heterogeneity of Rat GABA A Receptors....Pages 365-374 Subunit and Subtype-Specific Antibodies to the GABA-A/Benzodiazepine Receptor Complex....Pages 375-380 The Differential Expression Pattern of the mRNAs Encoding β Subunits ( β 1 , β 2 and β 3 ) of GABA A Receptor in Rat Brain....Pages 381-390 “In Vivo” Inhibition of GABAergic Transmission Increases 35 S-TBPS Binding in the Rat Brain....Pages 391-404 123-I-Iomazenil-SPECT in Patients with Focal Epilepsies — A Comparative Study with 99m Tc-HMPAO-SPECT, CT and MR....Pages 405-412 Expression of the GABA B Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C....Pages 413-420 Structure and Expression of Inhibitory Glycine Receptors....Pages 421-429 Heterogeneous Distribution of Glutamate Receptor Subtypes in Hippocampus as Revealed by Calcium Fluorometry....Pages 431-440 Excitatory Amino Acid Receptors in the Xenopus Oocyte Expression System....Pages 441-453 Novel Fourth Binding Sites of [ 3 H]Spermidine within the NMDA Receptor Complex....Pages 455-475 Solubilization of the NMDA Receptor Ion Channel Complex from Rat Brain....Pages 477-481 NMDA Receptor Agonists: Relationships between Structure and Biological Activity....Pages 483-487 Back Matter....Pages 489-498 Proceedings of the Third International Symposium on Neurotransmitter Receptors, held in Hiroshima, Japan, February 5--8, 1990