اختلالات نوروسایکیاتری و اپی‌ژنتیک (اپی‌ژنتیک ترجمه‌ای)

__Neuropsychiatric Disorders and Epigenetics__ is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Content: Front matter,Copyright,List of Contributors,PrefaceEntitled to full textSection I: Neuropsychiatric Disorders and Epigenetics: General AspectsChapter 1 - Introduction to neuropsychiatric disorders and epigenetics, Pages 3-8, J. Peedicayil, D.R. Grayson, D.H. Yasui Chapter 2 - Environmental factors and epigenetics of neuropsychiatric disorders, Pages 9-33, A. Hoffmann, D. Spengler Chapter 3 - Epigenetic biomarkers in neuropsychiatric disorders, Pages 35-66, C.-C. Lin, T.-L. Huang Chapter 4 - Epigenetics and cognitive disorders—translational aspects, Pages 69-91, F. Coppedè Chapter 5 - Epigenetics in pervasive developmental disorders: translational aspects, Pages 93-106, T. Kubota Chapter 6 - Epigenetic causes of intellectual disability—the fragile X syndrome paradigm, Pages 107-127, E. Tabolacci, G. Neri Chapter 7 - Epigenetics of attention-deficit hyperactivity disorder, Pages 129-140, N. Perroud, S. Weibel, J.-M. Aubry, A. Dayer Chapter 8 - The epigenetics of brain aging and psychiatric disorders, Pages 141-162, H. Gong, X. Xu Chapter 9 - Epigenetics and Down syndrome, Pages 163-184, A.D. Dekker, P.P. De Deyn, M.G. Rots Chapter 10 - Epigenetics and multiple sclerosis, Pages 185-213, L. Kular, G. Castelo-Branco, M. Jagodic Chapter 11 - Epigenetics and migraine, Pages 215-231, S.H. Gan, M.M. Shaik Chapter 12 - The role of epigenetics in the pathophysiology of epilepsy, Pages 233-260, S.M. Nam, K.-O. Cho Chapter 13 - Epigenetic dysregulation in brain tumors and neurodevelopment, Pages 261-276, M.M. Hefti, N. Tsankova Chapter 14 - Epigenetics and cerebrovascular diseases, Pages 277-298, C. Soriano-Tárraga, J. Jiménez-Conde, J. Roquer Chapter 15 - Epigenetics and eating disorders, Pages 299-307, H. Frieling, V. Buchholz Chapter 16 - Epigenetics and obesity, Pages 309-334, B.M. Shewchuk Chapter 17 - Epigenetics and drug addiction: translational aspects, Pages 335-360, J. Feng Chapter 18 - Epigenetics and alcohol use disorders, Pages 361-397, S. Sagarkar, A. Sakharkar Chapter 19 - Neuropsychiatric disorders and epigenetics: summary and outlook, Pages 400-406, J. Peedicayil, D.R. Grayson, D.H. Yasui Index, Pages 409-423

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.

Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.

• Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
• Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
• Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

This book will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development