NeuroPET : Positron Emission Tomography in Neuroscience and Clinical Neurology

Positron emission tomography (PET) provides unbiased in vivo measurement of local tracer activity at very high sensitivity. This is a unique property unmatched by other imaging modalities. When PETwas introduced into medicine more than 25years ago, the first organ of major interest was the brain. Since then, PET has flourished as an extremely powerful and versatile tool in scientific brain studies, whereas its use as a diagnostic tool in clinical neurology remains limited. This is in contrast to its use in otherapplications,particularlyoncology,where its value in clinical diagnosis is more widely appreciated. Wethink this situation is unfortu­ nate, because PET can contribute more to clinical neurology and clinical neuro­ science than is generally perceived today. Realization of its potential will require very close cooperation between PETexperts and clinicians and the integration of PET into clinical studies. Thus, in this book we review PETin neuroscience,with particular emphasis on findings that indicate its potential for improving diagno­ sis and treatment in neurology and psychiatry. We want to improve the trans­ ferability of the enormous scientific advances in brain PET into clinical care so as to produce tangible human benefit [1]. Wewish to guide both nuclear medicine specialists and also neurologists and psychiatrists in the use of PET. We there­ fore focus on practical and potentially clinically relevant issues, identifying solid ground as well as open questions that require further research, and we see this targeted presentation as complementary to more general PET textbooks and reviews. This is the only comprehensive and up-to-date book on neurological PET. Its goal is to facilitate cooperation between PET experts, neuroscientists and clinicians. We review PET in neuroscience with particular emphasis on findings that indicate its potential for improving diagnosis and treatment in neurology and psychiatry. We want to improve the transfer of the huge scientific developments in brain PET into clinical care to produce tangible human benefit. We therefore focus on practical and potentially clinically relevant issues and identify solid ground as well as open questions. In addition, the book includes major chapters on the methodological background, including tracer physiology and kinetic modeling, and a comprehensive literature review Front Matter....Pages I-XV Introduction....Pages 1-5 Clinical Studies....Pages 7-142 Imaging Brain Function....Pages 143-185 Data Acquisition, Reconstruction, Modeling, Statistics....Pages 187-234 Back Matter....Pages 235-297 - Authors are all experts in the field; Herscovitch is head of PET Imaging at NIH.- PET is becoming dominant technology for diagnosis in Neurology; books have not caught up. NeuroPET is ahead of the curve.