Neuropeptide Systems as Targets for Parasite and Pest Control (Advances in Experimental Medicine and Biology, 692)

The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems. Strategies for insecticides and parasiticides : a review / Debra Woods ... [et al.] Nonpeptide ligands for peptidergic G protein coupled receptors / Timothy G. Geary Interaction of mimetic analogs of insect kinin neuropeptides with arthropod receptors / Ronald J. Nachman and Patricia V. Pietrantonio Neuropeptides in helminths : occurrence and distribution / Nikki J. Marks and Aaron G. Maule Neuropeptide physiology in helminths / Angela Mousley ... [et al.] Neuropeptide gene families in Caenorhabditis elegans / Chris Li and Kyuhyung Kim Control of nematode parasites with agents acting on neuromusculature systems : lessons for neuropeptide ligand discovery / Richard J. Martin and Alan P. Robertson Neuropeptide signaling in insects / Miriam Altstein and Dick R. Nassel Neuropeptide physiology in insects / William G. Bendena Neuropeptide biology in Drosophila / Elke Clynen ... [et al.] Neuropeptide receptors as possible targets for development of insect pest control agents / Matthias B. Van Hiel ... [et al.]. Front Matter....Pages i-xviii Receptor-Based Discovery Strategies for Insecticides and Parasiticides: A Review....Pages 1-9 Nonpeptide Ligands for Peptidergic G Protein-Coupled Receptors....Pages 10-26 Interaction of Mimetic Analogs of Insect Kinin Neuropeptides with Arthropod Receptors....Pages 27-48 Neuropeptides in Helminths: Occurrence and Distribution....Pages 49-77 Neuropeptide Physiology in Helminths....Pages 78-97 Neuropeptide Gene Families in Caenorhabditis elegans ....Pages 98-137 Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery....Pages 138-154 Neuropeptide Signaling in Insects....Pages 155-165 Neuropeptide Physiology in Insects....Pages 166-191 Neuropeptide Biology in Drosophila ....Pages 192-210 Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents....Pages 211-226 Back Matter....Pages 227-230 This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems. The organization of the chapters is intended to provide an overview of the organism-level biology of neuropeptidergic function in insects and helminths, progressing to an understanding of the molecular biology of the genes that encode their precursors and receptors in these organisms. We include for perspective consideration of the state of the art in discovery of insecticides and anthelmintics, a review of drugs that affect similar systems in nematodes, and a summary of drug discovery efforts that target mammalian neuropeptide receptors for therapy of non-infectious diseases in humans