Neuropathology And Genetics Of Dementia (advances In Experimental Medicine And Biology) (volume 490)

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland. For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia. A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book. Front Matter....Pages i-xiii Can the Physician Predict the Neuropathologist?....Pages 1-4 The Molecular Parameters of Tau Pathology....Pages 5-19 Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17....Pages 21-37 Argyrophilic Grain Disease....Pages 39-58 Tau Pathology in Neurons and Glial Cells of Aged Baboons....Pages 59-69 Human Tau Transgenic Mice....Pages 71-83 Regulation of Alzheimer ß-Amyloid Precursor Trafficking and Metabolism....Pages 85-100 Role of Type 10 17ß-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer’s Disease....Pages 101-110 The Spectrum of Vascular Disease in Dementia....Pages 111-122 Transgenic Mouse Models of Cerebral Amyloid Angiopathy....Pages 123-128 Alpha-Synuclein....Pages 129-134 Dementia with Lewy Bodies....Pages 135-145 Mouse Models of α-Synucleinopathy and Lewy Pathology....Pages 147-167 Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases....Pages 169-186 Perisomatic Granules of Hippocampal CA1 Neurons in Alzheimer’s Disease, Pre-Alzheimer Stage and Pick’s Disease: An Overlooked Pathological Entity....Pages 187-198 Pathological Mechanisms in Polyglutamine Expansion Diseases....Pages 199-210 Dementia in the Neuronal Ceroidlipofuscinoses....Pages 211-217 Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis....Pages 219-228 Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing....Pages 229-251 Back Matter....Pages 253-255