Neuroinflammation: Mechanisms and Management (Contemporary Neuroscience)

The field of neuroinflammation is evolving rapidly and now yielding many new potential therapeutics for clinical trials. In this thoroughly updated and revised edition of his much praised book, Neuroinflammation: Mechanisms and Management, Second Edition, Paul L. Wood and a panel of leading researchers capture all these new developments in a masterful synthesis of what is known today about the inflammatory mediators and the cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis. Up-to-date and insightful, Neuroinflammation: Mechanisms and Management, Second Edition summarizes all the recent discoveries now playing a key role in both developing molecular targets and designing a new generation of drugs for acute and chronic neurodegenerative disorders alike. Front Matter....Pages i-xi Front Matter....Pages 1-1 Microglia....Pages 3-27 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration....Pages 29-88 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration....Pages 89-97 Roles of Chemokines and Their Receptors in Neuroinflammation....Pages 99-115 Neurotoxic Mechanisms of Nitric Oxide....Pages 117-135 Chronic Intracerebral LPS as a Model of Neuroinflammation....Pages 137-150 Peroxisome Proliferator-Activated Receptor Gamma Agonists....Pages 151-169 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases....Pages 171-186 Front Matter....Pages 187-187 Inflammation and Potential Anti-Inflammatory Approaches in Stroke....Pages 189-213 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury....Pages 215-235 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia....Pages 237-245 Front Matter....Pages 247-247 Neuroinflammatory Environments Promote Amyloid-ß Deposition and Posttranslational Modification....Pages 249-266 Microglial Responses in Alzheimer’s Disease....Pages 267-282 The Amyloid Hypothesis of Cognitive Dysfunction....Pages 283-293 The Cerebellum in AD....Pages 295-300 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration....Pages 301-329 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease....Pages 331-342 Front Matter....Pages 343-343 Experimental Autoimmune Encephalomyelitis....Pages 345-357 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis....Pages 359-377 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases....Pages 379-387 Front Matter....Pages 389-389 Inflammatory Mechanisms in Parkinson’s Disease....Pages 391-403 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration....Pages 405-416 Back Matter....Pages 417-419 Over the last decade, the neuroinflammatory hypothesis of neurodegeneration has become well established.