NEUROINFLAMMATION IN NEURONAL DEATH AND REPAIR, Volume 82 (International Review of Neurobiology.) (International Review of Neurobiology.)

Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies. Content: Inflammatory Mediators Leading to Protein Misfolding and Uncompetitive/Fast Off‐Rate Drug Therapy for Neurodegenerative Disorders Review Article Pages 1-27 Stuart A. Lipton, Zezong Gu, Tomohiro Nakamura Innate Immunity and Protective Neuroinflammation: New Emphasis on the Role of Neuroimmune Regulatory Proteins Review Article Pages 29-55 M. Griffiths, J.W. Neal, P. Gasque Glutamate Release from Astrocytes in Physiological Conditions and in Neurodegenerative Disorders Characterized by Neuroinflammation Review Article Pages 57-71 Sabino Vesce, Daniela Rossi, Liliana Brambilla, Andrea Volterra The High‐Mobility Group Box 1 Cytokine Induces Transporter‐Mediated Release of Glutamate from Glial Subcellular Particles (Gliosomes) Prepared from in Situ ‐Matured Astrocytes Review Article Pages 73-93 Giambattista Bonanno, Luca Raiteri, Marco Milanese, Simona Zappettini, Edon Melloni, Marco Pedrazzi, Mario Passalacqua, Carlo Tacchetti, Cesare Usai, Bianca Sparatore The Role of Astrocytes and Complement System in Neural Plasticity Review Article Pages 95-111 Milos Pekny, Ulrika Wilhelmsson, Yalda Rahpeymai Bogestål, Marcela Pekna New Insights into the Roles of Metalloproteinases in Neurodegeneration and Neuroprotection Review Article Pages 113-135 A.J. Turner, N.N. Nalivaeva Relevance of High‐Mobility Group Protein Box 1 to Neurodegeneration Review Article Pages 137-148 Silvia Fossati, Alberto Chiarugi Early Upregulation of Matrix Metalloproteinases Following Reperfusion Triggers Neuroinflammatory Mediators in Brain Ischemia in Rat Review Article Pages 149-169 Diana Amantea, Rossella Russo, Micaela Gliozzi, Vincenza Fratto, Laura Berliocchi, G. Bagetta, G. Bernardi, M. Tiziana Corasaniti The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis Review Article Pages 171-186 Diego Centonze, Silvia Rossi, Alessandro Finazzi‐Agrò, Giorgio Bernardi, Mauro Maccarrone Chemokines and Chemokine Receptors: Multipurpose Players in Neuroinflammation Review Article Pages 187-204 Richard M. Ransohoff, LiPing Liu, Astrid E. Cardona Systemic and Acquired Immune Responses in Alzheimer's Disease Review Article Pages 205-233 Markus Britschgi, Tony Wyss‐Coray Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder? Review Article Pages 235-246 Joseph Rogers, Diego Mastroeni, Brian Leonard, Jeffrey Joyce, Andrew Grover Cytokines and Neuronal Ion Channels in Health and Disease Review Article Pages 247-263 Barbara Viviani, Fabrizio Gardoni, Marina Marinovich Cyclooxygenase‐2, Prostaglandin E 2 , and Microglial Activation in Prion Diseases Review Article Pages 265-275 Luisa Minghetti, Maurizio Pocchiari Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function‐Based and Target‐Based Discovery Approaches Review Article Pages 277-296 Linda J. Van Eldik, Wendy L. Thompson, Hantamalala Ralay Ranaivo, Heather A. Behanna, D. Martin Watterson Oxidative Stress and the Pathogenesis of Neurodegenerative Disorders Review Article Pages 297-325 Ashley Reynolds, Chad Laurie, R. Lee Mosley, Howard E. Gendelman Differential Modulation of Type 1 and Type 2 Cannabinoid Receptors along the Neuroimmune Axis Review Article Pages 327-337 Sergio Oddi, Paola Spagnuolo, Monica Bari, Antonella D'Agostino, Mauro Maccarrone Effects of the HIV‐1 Viral Protein TAT on Central Neurotransmission: Role of Group I Metabotropic Glutamate Receptors Review Article Pages 339-356 Elisa Neri, Veronica Musante, Anna Pittaluga Evidence to Implicate Early Modulation of Interleukin‐1β Expression in the Neuroprotection Afforded by 17β‐Estradiol in Male Rats Undergone Transient Middle Cerebral Artery Occlusion Review Article Pages 357-372 Olga Chiappetta, Micaela Gliozzi, Elisa Siviglia, Diana Amantea, Luigi A. Morrone, Laura Berliocchi, G. Bagetta, M. Tiziana Corasaniti A Role for Brain Cyclooxygenase‐2 and Prostaglandin‐E 2 in Migraine: Effects of Nitroglycerin Review Article Pages 373-382 Cristina Tassorelli, Rosaria Greco, Marie Therèse Armentero, Fabio Blandini, Giorgio Sandrini, Giuseppe Nappi The Blockade of K + ‐ATP Channels has Neuroprotective Effects in an In Vitro Model of Brain Ischemia Review Article Pages 383-395 Robert Nisticò, Silvia Piccirilli, L. Sebastianelli, Giuseppe Nisticò, G. Bernardi, N.B. Mercuri Retinal Damage Caused by High Intraocular Pressure–Induced Transient Ischemia is Prevented by Coenzyme Q10 in Rat Review Article Pages 397-406 Carlo Nucci, Rosanna Tartaglione, Angelica Cerulli, R. Mancino, A. Spanò, Federica Cavaliere, Laura Rombol`, G. Bagetta, M. Tiziana Corasaniti, Luigi A. Morrone Evidence Implicating Matrix Metalloproteinases in the Mechanism Underlying Accumulation of IL‐1β and Neuronal Apoptosis in the Neocortex of HIV/gp120‐Exposed Rats Review Article Pages 407-421 Rossella Russo, Elisa Siviglia, Micaela Gliozzi, Diana Amantea, Annamaria Paoletti, Laura Berliocchi, G. Bagetta, M. Tiziana Corasaniti Neuroprotective Effect of Nitroglycerin in a Rodent Model of Ischemic Stroke: Evaluation of Bcl‐2 Expression Review Article Pages 423-435 Rosaria Greco, Diana Amantea, Fabio Blandini, Giuseppe Nappi, Giacinto Bagetta, M. Tiziana Corasaniti, Cristina Tassorelli Series Editors Page II Contents Pages V-XII Contributors to Volume 82 Pages XIII-XX Preface Pages XXI-XXII Giacinto Bagetta, M. Tiziana Corasaniti, Stuart A. Lipton Foreword Pages XXIII-XXIV Index Pages 437-450 Contents of Previous Volumes Pages 451-474 Discusses the mechanisms of neuroinflammation, its role in the context of different neurodegenerative diseases (ie Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis and pain) and on the potential approaches for future therapeutic strategies.