Neuroimmune Diseases: From Cells to the Living Brain (Contemporary Clinical Neuroscience)

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases Front Matter ....Pages i-vii Front Matter ....Pages 1-1 Overview of Mechanisms Underlying Neuroimmune Diseases (Sandip Ashok Sonar, Girdhari Lal)....Pages 3-62 Roles of Effector T Cells in Neurological Autoimmunity (Yuki Fujita, Toshihide Yamashita)....Pages 63-81 The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders (Arash Pourgholaminejad, Foozhan Tahmasebinia)....Pages 83-107 Significance of Autoantibodies (Christiane S. Hampe)....Pages 109-142 Immune Tolerance in Autoimmune Central Nervous System Disorders (Sundararajan Jayaraman, Bellur S. Prabhakar)....Pages 143-166 The Roles of Regulatory T Cells in Central Nervous System Autoimmunity (Brooke A. Keating, Justin G. Lees, Gila Moalem-Taylor)....Pages 167-193 Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases (Hamid Salimi, Robyn S. Klein)....Pages 195-234 Structural and Functional Characteristics of the Human Blood-Nerve Barrier with Translational Implications to Peripheral Nerve Autoimmune Disorders (Eroboghene E. Ubogu)....Pages 235-302 Multi-actions of Microglia (Célestine Brunois, Laurence Ris)....Pages 303-328 Autoimmune Astrocytopathy (Jorge Correale, María I. Gaitán)....Pages 329-355 Genetic Factors in Neuroimmune Diseases (Alessandro Didonna, Ester Cantó)....Pages 357-386 General Principles of Immunotherapy in Neurological Diseases (Paulus S. Rommer, Michael Hecker, Tobias Zrzavy, Nina Boxberger, Uwe K. Zettl)....Pages 387-421 Front Matter ....Pages 423-423 Postinfectious Immune-Mediated Neurological Diseases (Marios Hadjivassiliou, Panagiotis Zis)....Pages 425-437 Paraneoplastic Neurological Syndromes (Sergio Muñiz-Castrillo, Jérôme Honnorat)....Pages 439-485 Multiple Sclerosis (Jun-ichi Kira, Noriko Isobe)....Pages 487-521 Neuromyelitis Optica Spectrum Disorder (Samira Saadoun, Vincent T. W. Chang, Marios C. Papadopoulos)....Pages 523-541 Atypical Inflammatory Demyelinating Syndromes of the Central Nervous System (Todd A. Hardy)....Pages 543-566 Autoimmune Limbic Encephalitis (Shahar Shelly, Ram Narayan, Divyanshu Dubey)....Pages 567-597 Autoimmune Ataxias (Marios Hadjivassiliou, Hiroshi Mitoma, Mario Manto)....Pages 599-620 Stiff-Person Syndrome Spectrum Disorders (José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez)....Pages 621-649 Central Nervous System Vasculitis and Related Diseases (Hiroshi Mitoma, Mario Manto, Jordi Gandini)....Pages 651-682 Behçet’s Syndrome and the Nervous System Involvement (Ugur Uygunoglu, Aksel Siva)....Pages 683-697 Neuroinflammation and Sjogren’s Syndrome (Pasquale Annunziata)....Pages 699-709 Guillain-Barré Syndrome (Yhojan Rodríguez, Christopher Chang, Diana C. González-Bravo, M. Eric Gershwin, Juan-Manuel Anaya)....Pages 711-736 Chronic Inflammatory Demyelinating Polyneuropathy (Miki Suzuki, Gérard Said)....Pages 737-764 Myasthenia Gravis and Other Immune-Mediated Disorders of the Neuromuscular Junction (Nils Erik Gilhus)....Pages 765-785 Myositis (Liliana R. Santos, David Isenberg)....Pages 787-808 Back Matter ....Pages 809-827