Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders : Achievements and Perspectives

"This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn to potential translational aspects of research in the field, with discussion of emerging innovative perspectives. Neuroimaging research has shown that abnormalities of brain structure and function associated with psychiatric disorders do not reflect the boundaries of current diagnostic categories. However, neuroimaging findings are being reconsidered in the light of recent research proposals aimed at re-conceptualizing classification systems in Psychiatry. Written by leading experts, this book will appeal to all with an interest in the field, including researchers, clinicians, and trainees." -- Prové de l'editor Front Matter ....Pages i-x Neuroimaging: Diagnostic Boundaries and Biomarkers (Silvana Galderisi, Giulia Maria Giordano, Lynn E. DeLisi)....Pages 1-56 Neuroimaging and Psychopathological Domains (Armida Mucci, Silvana Galderisi, Antonella Amodio, Thomas Dierks)....Pages 57-155 Neuroimaging of Neurotransmitter Alterations in Schizophrenia and Its Relevance for Negative Symptoms (Andreas Heinz, Stefan Borgwardt, Lynn E. DeLisi)....Pages 157-169 Neuroimaging and Genetics (Lynn E. DeLisi, Stefan Borgwardt, Andreas Heinz)....Pages 171-182 Neuroimaging and the Longitudinal Course of Schizophrenia (Geraldo F. Busatto, Pedro G. P. Rosa, Paolo Fusar-Poli, Lynn E. DeLisi)....Pages 183-218 Neuroimaging and the At-Risk Mental State (Yu-Shiuan Lin, Paolo Fusar-Poli, Stefan Borgwardt)....Pages 219-265 Neuroimaging and Antipsychotics (Antonio Vita, Florian Schlagenhauf, Stefano Barlati, Andreas Heinz)....Pages 267-301 Research Perspectives for Neuroimaging of Schizophrenia Spectrum Disorders (Eleanor Scutt, Stefan Borgwardt, Paolo Fusar-Poli)....Pages 303-325 Toward Clinical Translation of Neuroimaging Research in Schizophrenia and Other Primary Psychotic Disorders (Annarita Vignapiano, Lynn E. DeLisi, Silvana Galderisi)....Pages 327-345