Neuroimaging diagnosis for Alzheimer's disease and other dementias

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields. Front Matter ....Pages i-viii Epidemiology of Dementia in Japan (Takashi Asada)....Pages 1-10 Diagnostic Criteria for Alzheimer’s Disease (Tetsuaki Arai)....Pages 11-19 Structural Neuroimaging in Alzheimer’s Disease (Hiroshi Matsuda, Etsuko Imabayashi)....Pages 21-38 MRI Diagnosis in Other Dementias (Aya M. Tokumaru, Yuko Saito, Shigeo Murayama, Keita Sakurai)....Pages 39-115 Diffusion Tensor Imaging in Dementia (Toshiaki Taoka)....Pages 117-128 Arterial Spin Labeling in Dementia (Takashi Yoshiura)....Pages 129-138 Proton Magnetic Resonance Spectroscopy for Dementia (Akihiko Shiino)....Pages 139-172 Toward Clinical Application of Resting-State Functional Magnetic Resonance Imaging to Dementia (Yousuke Ogata, Takashi Hanakawa)....Pages 173-188 FDG-PET in Alzheimer’s Disease (Yoshitaka Inui, Kengo Ito, Takashi Kato)....Pages 189-198 Tau PET in Neurodegenerative Diseases Manifesting Dementia (Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo)....Pages 199-210 Brain Perfusion SPECT in Alzheimer’s Disease (Kiyotaka Nemoto)....Pages 211-220 Neuroimaging of Dementia with Lewy Bodies (Haruo Hanyu)....Pages 221-231 Neuroimaging of Frontotemporal Lobe Degeneration (Seigo Nakano)....Pages 233-242 Neuroimaging Study of Alzheimer’s Disease in Volunteer-Based Cohort (Miharu Samuraki, Ichiro Matsunari, Masahito Yamada)....Pages 243-255 Handling of MRI Data in a Multicenter Study (Norihide Maikusa)....Pages 257-267 Standardization and Quality Control of Brain PET Data in a Multicenter Study (Michio Senda)....Pages 269-279