Neurohumoral Regulation of Coronary Flow : Role of the Endothelium

During the last decade we have witnessed a rapid expansion of our knowledge of the role of the endothelium in the control of vascular tone and hemostasis. In paricular, developments in molecular biology have enabled us to understand its physiology in greater detail. Furthermore, it is now clear that dysfunction of the endothelium contributes to various cardiovascular diseases. This is especially true for the coronary vascular bed. Development of atherosclerosis, disturbed vasomotor tone in stable ischemic syndromes, and the interaction of thrombocytes with the endothelium in acute ischemic syndrome are all consequences of endothelium dysfunction. Also, secondary changes in endothelial function have been described, for instance in chronic heart failure. This monograph reviews the present knowledge of the role of the endothelium in the control of coronary flow. The authors lead the reader through this topic starting at the basic physiology of endothelial function and the principles of coronary flow regulation. Next, the use of modern clinical techniques to evaluate endothelial function such as positron emission tomography and angioscopy are discussed. Subsequently, several pathophysiological processes and the role of endothelium are addressed. Finally, the interaction of various presently used cardiovascular drugs with the endothelium is indicated. It is the combination of basic sciences with clinical observations in this book which may be appreciated by a large number of scientists and physicians active in the field of cardiovascular disease. It is also this combination of different disciplines which will determine future developments and new avenues in pharmacotherapy involving the endothelium. Front Matter....Pages i-ix Endothelial Function....Pages 1-18 Pathophysiology of Coronary Flow Regulation....Pages 19-26 Neural Regulation of Coronary Blood Flow and Its Impact on Angina Pectoris and Myocardial Ischemia....Pages 27-40 The Role of Molecular-Genetic Tools in Vascular Research....Pages 41-55 The Coronary Vascular Wall Post-PTCA....Pages 57-71 Positron Emission Tomography and the Detection of Endothelial Dysfunction....Pages 73-88 Neurohumoral Regulation in Silent Myocardial Ischemia....Pages 89-101 Endothelium, Lipoproteins and Atherosclerosis. Effects of Lipid Lowering and Lipid Modification Therapy....Pages 103-119 Local Effects of Angiotensin-Converting Enzyme Inhibitors on the Vascular Wall....Pages 121-135 From Thomas Lauder-Brunton to the Endogenous Nitrate....Pages 137-145 Back Matter....Pages 147-150