Neuroglia in Neurodegenerative Diseases (Advances in Experimental Medicine and Biology Book 1175)

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons. Front Matter ....Pages i-x The Concept of Neuroglia (Alexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura)....Pages 1-13 Evolution of Neuroglia (Alexei Verkhratsky, Margaret S. Ho, Vladimir Parpura)....Pages 15-44 Physiology of Astroglia (Alexei Verkhratsky, Vladimir Parpura, Nina Vardjan, Robert Zorec)....Pages 45-91 Gliocrine System: Astroglia as Secretory Cells of the CNS (Nina Vardjan, Vladimir Parpura, Alexei Verkhratsky, Robert Zorec)....Pages 93-115 Physiology of Oligodendroglia (Arthur M. Butt, Maria Papanikolaou, Andrea Rivera)....Pages 117-128 Physiology of Microglia (Tuan Leng Tay, Micaël Carrier, Marie-Ève Tremblay)....Pages 129-148 General Pathophysiology of Astroglia (Alexei Verkhratsky, Margaret S. Ho, Nina Vardjan, Robert Zorec, Vladimir Parpura)....Pages 149-179 Neuroglia in Ageing (Alexei Verkhratsky, Robert Zorec, Jose Julio Rodriguez-Arellano, Vladimir Parpura)....Pages 181-197 Astroglia in Leukodystrophies (M. S. Jorge, Marianna Bugiani)....Pages 199-225 Astrocytes in Motor Neuron Diseases (Chiara F. Valori, Giulia Guidotti, Liliana Brambilla, Daniela Rossi)....Pages 227-272 Astroglia in Alzheimer’s Disease (Alexei Verkhratsky, Vladimir Parpura, Jose Julio Rodriguez-Arellano, Robert Zorec)....Pages 273-324 Oligodendroglial Cells in Alzheimer’s Disease (Arthur M. Butt, Irene Chacon De La Rocha, Andrea Rivera)....Pages 325-333 Microglia in Parkinson’s Disease (Margaret S. Ho)....Pages 335-353 Astrocytes in Huntington’s Disease (Michelle Gray)....Pages 355-381 Induced Pluripotent Stem Cell-Derived Astroglia: A New Tool for Research Towards the Treatment of Alzheimer’s Disease (Rebecca Atkinson-Dell, Lisa Mohamet)....Pages 383-405 This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes, and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer's, Parkinson's, and Huntington's. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons