Neurogenic Inflammation in Health and Disease (Volume 8) (NeuroImmune Biology, Volume 8)

Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain. *Neurogenic inflammation in historical perspective*Cardiac protection by nociceptive afferents*Molecular mechanisms of nociception*Sensory mechanisms in migraine pathophysiology*Vagal signalling of visceral inflammation*Neurogenic mechanisms in arthritis*Therapeutic implications of vanilloid-type compounds Content: Series Editor Page ii Volume Editor Page iii Copyright Page Page iv Foreword: Neurogenic Inflammation Coming of Age Pages vii-xiv István Berczi Preface Page xv G. Jancsó List of Contributors Pages xvii-xix Sensory Nerves as Modulators of Cutaneous Inflammatory Reactions in Health and Disease Review Article Pages 1,3-36 Gábor Jancsó, Márta katona, Viktor Horváth, Péter Sántha, József Nagy The Nature and Electrophysiological Properties of the Afferent Neurons Involved in Neurogenic Inflammation in the Skin Review Article Pages 37,39-48 Bruce Lynn Peptidergic Innervation of Blood Vessels Review Article Pages 49-74 Thomas M. Scott, Michael M. Scott Molecular Mechanisms of TRPV1-Mediated Pain Review Article Pages 75-99 Istvan Nagy, Cleoper C. Paule, John P.M. White The Role of the Vanilloid and Related Receptors in Nociceptor Function and Neuroimmune Regulation Review Article Pages 101-117 Daniel N. Cortright, Arpad Szallasi Somatostatin as an Anti-Inflammatory Neuropeptide: From Physiological Basis to Drug Development Review Article Pages 119,121-134 Erika Pintér, Zsuzsanna Helyes, József Németh, János Szolcsányi Effects of Bradykinin on Nociceptors Review Article Pages 135-168 Gábor Pethő, Peter W. Reeh The Inhibition of Neurogenic Inflammation Review Article Pages 169-189 Josef Donnerer, Ulrike Holzer-Petsche Neurogenic Vascular Responses in the Dura Mater and their Relevance for the Pathophysiology of Headaches Review Article Pages 191,193-209 Mária Dux, Karl Messlinger Neurogenic Mechanisms in Arthritis Review Article Pages 211-241 Lucy F. Donaldson Neurogenic Regulation of Bradykinin-Induced Synovitis Review Article Pages 243-265 Paul G. Green Capsaicin-Sensitive Sensory Nerves in Myocardial Ischemia–Reperfusion Injury and Ischemic Stress Adaptation: Role of Nitric Oxide and Calcitonin Gene-Related Peptide Review Article Pages 267-288 Péter Ferdinandy, Gábor Jancsó Tachykinins and Neurogenic Inflammation at Visceral Level Review Article Pages 289-320 Riccardo Patacchini, Carlo A. Maggi The Role of the Vagus Nerve in Afferent Signaling and Homeostasis During Visceral Inflammation Review Article Pages 321-338 Peter Holzer Subject Index Pages 339-346 Color Plates Pages C1-C4 Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain.

*Neurogenic inflammation in historical perspective
*Cardiac protection by nociceptive afferents
*Molecular mechanisms of nociception
*Sensory mechanisms in migraine pathophysiology
*Vagal signaling of visceral inflammation
*Neurogenic mechanisms in arthritis
*Therapeutic implications of vanilloid-type compounds Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. Neurogenic inflammation in historical perspective Cardiac protection by nociceptive afferents Molecular mechanisms of nociception Sensory mechanisms in migraine pathophysiology Vagal signaling of visceral inflammation Neurogenic mechanisms in arthritis Therapeutic implications of vanilloid-type compounds