Neurodegeneration and Alzheimer's disease : the role of diabetes, genetics, hormones, and lifestyle

Currently, the human population is on a collision course for a social and economic burden. As a consequence of changing demographics and an increase in human individuals over the age of 60, age-related neurodegenerative disorders are likely to become more prevalent. It is therefore essential to increase our understanding of such neurodegenerative disorders in order to be more pro-active in managing these diseases processes. The focus of this book is to provide a snapshot of recent advancements in the understanding of basic biological processes that modulate the onset and progression of neurodegenerative processes. This is tackled at the molecular, cellular and whole organism level. We hope that some of the recent discoveries outlined in this book will help to better define the basic biological mechanisms behind neurodegenerative processes and, in the long term, help in the development of novel therapeutic approaches. Read more... Abstract: Currently, the human population is on a collision course for a social and economic burden. As a consequence of changing demographics and an increase in human individuals over the age of 60, age-related neurodegenerative disorders are likely to become more prevalent. It is therefore essential to increase our understanding of such neurodegenerative disorders in order to be more pro-active in managing these diseases processes. The focus of this book is to provide a snapshot of recent advancements in the understanding of basic biological processes that modulate the onset and progression of neurodegenerative processes. This is tackled at the molecular, cellular and whole organism level. We hope that some of the recent discoveries outlined in this book will help to better define the basic biological mechanisms behind neurodegenerative processes and, in the long term, help in the development of novel therapeutic approaches Content: Current Understanding of Alzheimer's Disease and Other Neurodegenerative Diseases, and the Potential Role of Diet and Lifestyle in Reducing the Risks of Alzheimer's Disease and Cognitive Decline / Charles S Brennan, Margaret A Brennan, WMAD Binosha Fernando, Ralph N Martins -- Alzheimer's Disease and Other Neurodegenerative Diseases / Stephanie J Fuller, Hamid R Sohrabi, Kathryn G Goozee, Anoop Sankaranarayanan, Ralph N Martins -- Current and Developing Methods for Diagnosing Alzheimer's Disease / Stephanie J Fuller, Nicholas Carrigan, Hamid R Sohrabi, Ralph N Martins -- The Link Between Diabetes, Glucose Control, and Alzheimer's Disease and Neurodegenerative Diseases / Giuseppe Verdile, Paul E Fraser, Ralph N Martins -- Diet and Nutrition, and their Influence on Alzheimer's Disease and other Neurodegenerative Diseases / Stephanie R Rainey-Smith, Rhona Creegan, Stephanie J Fuller, Michele L Callisaya, Velandai Srikanth -- Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease / WMAD Binosha Fernando, Veer B Gupta, Vijay Jayasena, Charles S Brennan, Ralph N Martins -- Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease / Eugene Hone, Florence Lim, Ian J Martins -- Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds -- What Are the Most Promising Candidates? / Matthew J Sharman, Giuseppe Verdile, Shanmugam Kirubakaran, Gerald Münch -- Cognitive Impairments in Alzheimer's Disease and Other Neurodegenerative Diseases / Hamid R Sohrabi, Michael Weinborn -- Animal Models of Alzheimer's Disease / Prashant Bharadwaj -- The Products of Fermentation and Their Effects on Metabolism, Alzheimer's Disease, and Other Neurodegenerative Diseases: Role of Short-Chain Fatty Acids (SCFA) / WMAD Binosha Fernando, Charles S Brennan, Ralph N Martins -- Hormonal Expression Associated with Alzheimer's Disease and Neurodegenerative Diseases / Giuseppe Verdile, Anna M Barron, Ralph N Martins -- The Link Between Exercise and Mediation of Alzheimer's Disease and Neurodegenerative Diseases / Belinda Brown, Tejal M Shah -- Current and Prospective Treatments for Alzheimer's Disease (and Other Neurodegenerative Diseases) / Steve Pedrini, Mike Morici, Ralph N Martins -- The Role of Genetics in Alzheimer's Disease and Parkinson's Disease / Tenielle Porter, Aleksandra K Gozt, Francis L Mastaglia, Simon M Laws -- Final Thoughts Regarding Alzheimer's Disease, Diet, and Health.

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer's and other neurogenerative diseases

Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer's disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders' prevention and treatment.

An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer's disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer's disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book:

• Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease
• Discusses how genetic makeup can impact risk of Alzheimer's and Parkinson's disease
• Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis
• Discusses potential advantages of increasing antioxidant and micronutrient intake
• Reviews hormonal influences on neurodegeneration
• Examines the links between protein intake and Alzheimer's disease.

Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer's and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer's disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders' prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer's disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer's disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer's and Parkinson's disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer's disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions. La page de présentation indique : "Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer's and other neurogenerative diseases. Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer's disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism - and associated nutritional and lifestyle variables - may factor into such disorders' prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer's disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer's disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics"